Protein ENL (YEATS domain-containing protein 1)
1_MDNQC 6_ TVQVR 11_ LELGH 16_ RAQLR 21_ KKPTT 26_ EGFTH 31_ DWMVF 36_ VRGPE 41_ QCDIQ 46_ HFVEK 51_ VVFWL 56_ HDSFP 61_ KPRRV 66_ CKEPP 71_ YKVEE 76_ SGYAG 81_ FIMPI 86_ EVHFK 91_ NKEEP 96_ RKVCF 101_ TYDLF 106_ LNLEG 111_ NPPVN 116_ HLRCE 121_ KLTFN 126_ NPTTE 131_ FRYKL 136_ LRAGG 141_ VMVMP 146_ EGADT 151_ VSRPS 156_ PDYPM 161_ LPTIP 166_ LSAFS 171_ DPKKT 176_ KPSHG 181_ SKDAN 186_ KESSK 191_ TSKPH 196_ KVTKE 201_ HRERP 206_ RKDSE 211_ SKSSS 216_ KELER 221_ EQAKS 226_ SKDTS 231_ RKLGE 236_ GRLPK 241_ EEKAP 246_ PPKAA 251_ FKEPK 256_ MALKE 261_ TKLES 266_ TSPKG 271_ GPPPP 276_ PPPPP 281_ RASSK 286_ RPATA 291_ DSPKP 296_ SAKKQ 301_ KKSSS 306_ KGSRS 311_ APGTS 316_ PRTSS 321_ SSSFS 326_ DKKPA 331_ KDKSS 336_ TRGEK 341_ VKAES 346_ EPREA 351_ KKALE 356_ VEESN 361_ SEDEA 366_ SFKSE 371_ SAQSS 376_ PSNSS 381_ SSSDS 386_ SSDSD 391_ FEPSQ 396_ NHSQG 401_ PLRSM 406_ VEDLQ 411_ SEESD 416_ EDDSS 421_ SGEEA 426_ AGKTN 431_ PGRDS 436_ RLSFS 441_ DSESD 446_ NSADS 451_ SLPSR 456_ EPPPP 461_ QKPPP 466_ PNSKV 471_ SGRRS 476_ PESCS 481_ KPEKI 486_ LKKGT 491_ YDKAY 496_ TDELV 501_ ELHRR 506_ LMALR 511_ ERNVL 516_ QQIVN 521_ LIEET 526_ GHFNV 531_ TNTTF 536_ DFDLF 541_ SLDET 546_ TVRKL 551_QSCLE
1: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114)
2: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription