Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
1_MRSKG 6_ RARKL 11_ ATNNE 16_ CVYGN 21_ YPEIP 26_ LEEMP 31_ DADGV 36_ ASTPS 41_ LNIQE 46_ PCSPA 51_ TSSEA 56_ FTPKE 61_ GSPYK 66_ APIYI 71_ PDDIP 76_ IPAEF 81_ ELRES 86_ NMPGA 91_ GLGIW 96_ TKRKI 101_ EVGEK 106_ FGPYV 111_ GEQRS 116_ NLKDP 121_ SYGWE 126_ ILDEF 131_ YNVKF 136_ CIDAS 141_ QPDVG 146_ SWLKY 151_ IRFAG 156_ CYDQH 161_ NLVAC 166_ QINDQ 171_ IFYRV 176_ VADIA 181_ PGEEL 186_ LLFMK 191_ SEDYP 196_ HETMA 201_ PDIHE 206_ ERQYR 211_ CEDCD 216_ QLFES 221_ KAELA 226_ DHQKF 231_ PCSTP 236_ HSAFS 241_ MVEED 246_ FQQKL 251_ ESEND 256_ LQEIH 261_ TIQEC 266_ KECDQ 271_ VFPDL 276_ QSLEK 281_ HMLSH 286_ TEERE 291_ YKCDQ 296_ CPKAF 301_ NWKSN 306_ LIRHQ 311_ MSHDS 316_ GKHYE 321_ CENCA 326_ KVFTD 331_ PSNLQ 336_ RHIRS 341_ QHVGA 346_ RAHAC 351_ PECGK 356_ TFATS 361_ SGLKQ 366_ HKHIH 371_ SSVKP 376_ FICEV 381_ CHKSY 386_ TQFSN 391_ LCRHK 396_ RMHAD 401_ CRTQI 406_ KCKDC 411_ GQMFS 416_ TTSSL 421_ NKHRR 426_ FCEGK 431_ NHFAA 436_ GGFFG 441_ QGISL 446_ PGTPA 451_ MDKTS 456_ MVNMS 461_ HANPG 466_ LADYF 471_ GANRH 476_ PAGLT 481_ FPTAP 486_ GFSFS 491_ FPGLF 496_ PSGLY 501_ HRPPL 506_ IPASS 511_ PVKGL 516_ SSTEQ 521_ TNKSQ 526_ SPLMT 531_ HPQIL 536_ PATQD 541_ ILKAL 546_ SKHPS 551_ VGDNK 556_ PVELQ 561_ PERSS 566_ EERPF 571_ EKISD 576_ QSESS 581_ DLDDV 586_ STPSG 591_ SDLET 596_ TSGSD 601_ LESDI 606_ ESDKE 611_ KFKEN 616_ GKMFK 621_ DKVSP 626_ LQNLA 631_ SINNK 636_ KEYSN 641_ HSIFS 646_ PSLEE 651_ QTAVS 656_ GAVND 661_ SIKAI 666_ ASIAE 671_ KYFGS 676_ TGLVG 681_ LQDKK 686_ VGALP 691_ YPSMF 696_ PLPFF 701_ PAFSQ 706_ SMYPF 711_ PDRDL 716_ RSLPL 721_ KMEPQ 726_ SPGEV 731_ KKLQK 736_ GSSES 741_ PFDLT 746_ TKRKD 751_ EKPLT 756_ PVPSK 761_ PPVTP 766_ ATSQD 771_ QPLDL 776_ SMGSR 781_ SRASG 786_ TKLTE 791_ PRKNH 796_ VFGGK 801_ KGSNV 806_ ESRPA 811_ SDGSL 816_ QHARP 821_ TPFFM 826_ DPIYR 831_ VEKRK 836_ LTDPL 841_ EALKE 846_ KYLRP 851_ SPGFL 856_ FHPQM 861_ SAIEN 866_ MAEKL 871_ ESFSA 876_ LKPEA 881_ SELLQ 886_ SVPSM 891_ FNFRA 896_ PPNAL 901_ PENLL 906_ RKGKE 911_ RYTCR 916_ YCGKI 921_ FPRSA 926_ NLTRH 931_ LRTHT 936_ GEQPY 941_ RCKYC 946_ DRSFS 951_ ISSNL 956_ QRHVR 961_ NIHNK 966_ EKPFK 971_ CHLCD 976_ RCFGQ 981_ QTNLD 986_ RHLKK 991_ HENGN 996_ MSGTA 1001_ TSSPH 1006_ SELES 1011_ TGAIL 1016_ DDKED 1021_ AYFTE 1026_ IRNFI 1031_ GNSNH 1036_ GSQSP 1041_ RNVEE 1046_ RMNGS 1051_ HFKDE 1056_ KALVT 1061_ SQNSD 1066_ LLDDE 1071_ EVEDE 1076_ VLLDE 1081_ EDEDN 1086_ DITGK 1091_ TGKEP 1096_ VTSNL 1101_ HEGNP 1106_ EDDYE 1111_ ETSAL 1116_ EMSCK 1121_ TSPVR 1126_ YKEEE 1131_ YKSGL 1136_ SALDH 1141_ IRHFT 1146_ DSLKM 1151_ RKMED 1156_ NQYSE 1161_ AELSS 1166_ FSTSH 1171_ VPEEL 1176_ KQPLH 1181_ RKSKS 1186_ QAYAM 1191_ MLSLS 1196_ DKESL 1201_ HSTSH 1206_ SSSNV 1211_ WHSMA 1216_ RAAAE 1221_SSAIQ
1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis
2: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation