Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
1_MSGVV 6_ RTLSR 11_ CLLPA 16_ EAGGA 21_ RERRA 26_ GSGAR 31_ DAERE 36_ ARRRS 41_ RDIDA 46_ LLARE 51_ RRAVR 56_ RLVKI 61_ LLLGA 66_ GESGK 71_ STFLK 76_ QMRII 81_ HGREF 86_ DQKAL 91_ LEFRD 96_ TIFDN 101_ ILKGS 106_ RVLVD 111_ ARDKL 116_ GIPWQ 121_ YSENE 126_ KHGMF 131_ LMAFE 136_ NKAGL 141_ PVEPA 146_ TFQLY 151_ VPALS 156_ ALWRD 161_ SGIRE 166_ AFSRR 171_ SEFQL 176_ GESVK 181_ YFLDN 186_ LDRIG 191_ QLNYF 196_ PSKQD 201_ ILLAR 206_ KATKG 211_ IVEHD 216_ FVIKK 221_ IPFKM 226_ VDVGG 231_ QRSQR 236_ QKWFQ 241_ CFDGI 246_ TSILF 251_ MVSSS 256_ EYDQV 261_ LMEDR 266_ RTNRL 271_ VESMN 276_ IFETI 281_ VNNKL 286_ FFNVS 291_ IILFL 296_ NKMDL 301_ LVEKV 306_ KTVSI 311_ KKHFP 316_ DFRGD 321_ PHRLE 326_ DVQRY 331_ LVQCF 336_ DRKRR 341_ NRSKP 346_ LFHHF 351_ TTAID 356_ TENVR 361_ FVFHA 366_ VKDTI 371_ LQENL 376_KDIML
1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:22609986, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:16705036, PubMed:16787920, PubMed:23762476, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986)