Caveolin-1
1_MSGGK 6_ YVDSE 11_ GHLYT 16_ VPIRE 21_ QGNIY 26_ KPNNK 31_ AMADE 36_ LSEKQ 41_ VYDAH 46_ TKEID 51_ LVNRD 56_ PKHLN 61_ DDVVK 66_ IDFED 71_ VIAEP 76_ EGTHS 81_ FDGIW 86_ KASFT 91_ TFTVT 96_ KYWFY 101_ RLLSA 106_ LFGIP 111_ MALIW 116_ GIYFA 121_ ILSFL 126_ HIWAV 131_ VPCIK 136_ SFLIE 141_ IQCIS 146_ RVYSI 151_ YVHTV 156_ CDPLF 161_ EAVGK 166_ IFSNV 171_RINLQ
1: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)