Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
1_MAHSC 6_ RWRFP 11_ ARPGT 16_ TGGGG 21_ GGGRR 26_ GLGGA 31_ PRQRV 36_ PALLL 41_ PPGPP 46_ VGGGG 51_ PGAPP 56_ SPPAV 61_ AAAAA 66_ AAGSS 71_ GAGVP 76_ GGAAA 81_ ASAAS 86_ SSSAS 91_ SSSSS 96_ SSSAS 101_ SGPAL 106_ LRVGP 111_ GFDAA 116_ LQVSA 121_ AIGTN 126_ LRRFR 131_ AVFGE 136_ SGGGG 141_ GSGED 146_ EQFLG 151_ FGSDE 156_ EVRVR 161_ SPTRS 166_ PSVKT 171_ SPRKP 176_ RGRPR 181_ SGSDR 186_ NSAIL 191_ SDPSV 196_ FSPLN 201_ KSETK 206_ SGDKI 211_ KKKDS 216_ KSIEK 221_ KRGRP 226_ PTFPG 231_ VKIKI 236_ THGKD 241_ ISELP 246_ KGNKE 251_ DSLKK 256_ IKRTP 261_ SATFQ 266_ QATKI 271_ KKLRA 276_ GKLSP 281_ LKSKF 286_ KTGKL 291_ QIGRK 296_ GVQIV 301_ RRRGR 306_ PPSTE 311_ RIKTP 316_ SGLLI 321_ NSELE 326_ KPQKV 331_ RKDKE 336_ GTPPL 341_ TKEDK 346_ TVVRQ 351_ SPRRI 356_ KPVRI 361_ IPSSK 366_ RTDAT 371_ IAKQL 376_ LQRAK 381_ KGAQK 386_ KIEKE 391_ AAQLQ 396_ GRKVK 401_ TQVKN 406_ IRQFI 411_ MPVVS 416_ AISSR 421_ IIKTP 426_ RRFIE 431_ DEDYD 436_ PPIKI 441_ ARLES 446_ TPNSR 451_ FSAPS 456_ CGSSE 461_ KSSAA 466_ SQHSS 471_ QMSSD 476_ SSRSS 481_ SPSVD 486_ TSTDS 491_ QASEE 496_ IQVLP 501_ EERSD 506_ TPEVH 511_ PPLPI 516_ SQSPE 521_ NESND 526_ RRSRR 531_ YSVSE 536_ RSFGS 541_ RTTKK 546_ LSTLQ 551_ SAPQQ 556_ QTSSS 561_ PPPPL 566_ LTPPP 571_ PLQPA 576_ SSISD 581_ HTPWL 586_ MPPTI 591_ PLASP 596_ FLPAS 601_ TAPMQ 606_ GKRKS 611_ ILREP 616_ TFRWT 621_ SLKHS 626_ RSEPQ 631_ YFSSA 636_ KYAKE 641_ GLIRK 646_ PIFDN 651_ FRPPP 656_ LTPED 661_ VGFAS 666_ GFSAS 671_ GTAAS 676_ ARLFS 681_ PLHSG 686_ TRFDM 691_ HKRSP 696_ LLRAP 701_ RFTPS 706_ EAHSR 711_ IFESV 716_ TLPSN 721_ RTSAG 726_ TSSSG 731_ VSNRK 736_ RKRKV 741_ FSPIR 746_ SEPRS 751_ PSHSM 756_ RTRSG 761_ RLSSS 766_ ELSPL 771_ TPPSS 776_ VSSSL 781_ SISVS 786_ PLATS 791_ ALNPT 796_ FTFPS 801_ HSLTQ 806_ SGESA 811_ EKNQR 816_ PRKQT 821_ SAPAE 826_ PFSSS 831_ SPTPL 836_ FPWFT 841_ PGSQT 846_ ERGRN 851_ KDKAP 856_ EELSK 861_ DRDAD 866_ KSVEK 871_ DKSRE 876_ RDRER 881_ EKENK 886_ RESRK 891_ EKRKK 896_ GSEIQ 901_ SSSAL 906_ YPVGR 911_ VSKEK 916_ VVGED 921_ VATSS 926_ SAKKA 931_ TGRKK 936_ SSSHD 941_ SGTDI 946_ TSVTL 951_ GDTTA 956_ VKTKI 961_ LIKKG 966_ RGNLE 971_ KTNLD 976_ LGPTA 981_ PSLEK 986_ EKTLC 991_ LSTPS 996_ SSTVK 1001_ HSTSS 1006_ IGSML 1011_ AQADK 1016_ LPMTD 1021_ KRVAS 1026_ LLKKA 1031_ KAQLC 1036_ KIEKS 1041_ KSLKQ 1046_ TDQPK 1051_ AQGQE 1056_ SDSSE 1061_ TSVRG 1066_ PRIKH 1071_ VCRRA 1076_ AVALG 1081_ RKRAV 1086_ FPDDM 1091_ PTLSA 1096_ LPWEE 1101_ REKIL 1106_ SSMGN 1111_ DDKSS 1116_ IAGSE 1121_ DAEPL 1126_ APPIK 1131_ PIKPV 1136_ TRNKA 1141_ PQEPP 1146_ VKKGR 1151_ RSRRC 1156_ GQCPG 1161_ CQVPE 1166_ DCGVC 1171_ TNCLD 1176_ KPKFG 1181_ GRNIK 1186_ KQCCK 1191_ MRKCQ 1196_ NLQWM 1201_ PSKAY 1206_ LQKQA 1211_ KAVKK 1216_ KEKKS 1221_ KTSEK 1226_ KDSKE 1231_ SSVVK 1236_ NVVDS 1241_ SQKPT 1246_ PSARE 1251_ DPAPK 1256_ KSSSE 1261_ PPPRK 1266_ PVEEK 1271_ SEEGN 1276_ VSAPG 1281_ PESKQ 1286_ ATTPA 1291_ SRKSS 1296_ KQVSQ 1301_ PALVI 1306_ PPQPP 1311_ TTGPP 1316_ RKEVP 1321_ KTTPS 1326_ EPKKK 1331_ QPPPP 1336_ ESGPE 1341_ QSKQK 1346_ KVAPR 1351_ PSIPV 1356_ KQKPK 1361_ EKEKP 1366_ PPVNK 1371_ QENAG 1376_ TLNIL 1381_ STLSN 1386_ GNSSK 1391_ QKIPA 1396_ DGVHR 1401_ IRVDF 1406_ KEDCE 1411_ AENVW 1416_ EMGGL 1421_ GILTS 1426_ VPITP 1431_ RVVCF 1436_ LCASS 1441_ GHVEF 1446_ VYCQV 1451_ CCEPF 1456_ HKFCL 1461_ EENER 1466_ PLEDQ 1471_ LENWC 1476_ CRRCK 1481_ FCHVC 1486_ GRQHQ 1491_ ATKQL 1496_ LECNK 1501_ CRNSY 1506_ HPECL 1511_ GPNYP 1516_ TKPTK 1521_ KKKVW 1526_ ICTKC 1531_ VRCKS 1536_ CGSTT 1541_ PGKGW 1546_ DAQWS 1551_ HDFSL 1556_ CHDCA 1561_ KLFAK 1566_ GNFCP 1571_ LCDKC 1576_ YDDDD 1581_ YESKM 1586_ MQCGK 1591_ CDRWV 1596_ HSKCE 1601_ NLSDE 1606_ MYEIL 1611_ SNLPE 1616_ SVAYT 1621_ CVNCT 1626_ ERHPA 1631_ EWRLA 1636_ LEKEL 1641_ QISLK 1646_ QVLTA 1651_ LLNSR 1656_ TTSHL 1661_ LRYRQ 1666_ AAKPP 1671_ DLNPE 1676_ TEESI 1681_ PSRSS 1686_ PEGPD 1691_ PPVLT 1696_ EVSKQ 1701_ DDQQP 1706_ LDLEG 1711_ VKRKM 1716_ DQGNY 1721_ TSVLE 1726_ FSDDI 1731_ VKIIQ 1736_ AAINS 1741_ DGGQP 1746_ EIKKA 1751_ NSMVK 1756_ SFFIR 1761_ QMERV 1766_ FPWFS 1771_ VKKSR 1776_ FWEPN 1781_ KVSSN 1786_ SGMLP 1791_ NAVLP 1796_ PSLDH 1801_ NYAQW 1806_ QEREE 1811_ NSHTE 1816_ QPPLM 1821_ KKIIP 1826_ APKPK 1831_ GPGEP 1836_ DSPTP 1841_ LHPPT 1846_ PPILS 1851_ TDRSR 1856_ EDSPE 1861_ LNPPP 1866_ GIEDN 1871_ RQCAL 1876_ CLTYG 1881_ DDSAN 1886_ DAGRL 1891_ LYIGQ 1896_ NEWTH 1901_ VNCAL 1906_ WSAEV 1911_ FEDDD 1916_ GSLKN 1921_ VHMAV 1926_ IRGKQ 1931_ LRCEF 1936_ CQKPG 1941_ ATVGC 1946_ CLTSC 1951_ TSNYH 1956_ FMCSR 1961_ AKNCV 1966_ FLDDK 1971_ KVYCQ 1976_ RHRDL 1981_ IKGEV 1986_ VPENG 1991_ FEVFR 1996_ RVFVD 2001_ FEGIS 2006_ LRRKF 2011_ LNGLE 2016_ PENIH 2021_ MMIGS 2026_ MTIDC 2031_ LGILN 2036_ DLSDC 2041_ EDKLF 2046_ PIGYQ 2051_ CSRVY 2056_ WSTTD 2061_ ARKRC 2066_ VYTCK 2071_ IVECR 2076_ PPVVE 2081_ PDINS 2086_ TVEHD 2091_ ENRTI 2096_ AHSPT 2101_ SFTES 2106_ SSKES 2111_ QNTAE 2116_ IISPP 2121_ SPDRP 2126_ PHSQT 2131_ SGSCY 2136_ YHVIS 2141_ KVPRI 2146_ RTPSY 2151_ SPTQR 2156_ SPGCR 2161_ PLPSA 2166_ GSPTP 2171_ TTHEI 2176_ VTVGD 2181_ PLLSS 2186_ GLRSI 2191_ GSRRH 2196_ STSSL 2201_ SPQRS 2206_ KLRIM 2211_ SPMRT 2216_ GNTYS 2221_ RNNVS 2226_ SVSTT 2231_ GTATD 2236_ LESSA 2241_ KVVDH 2246_ VLGPL 2251_ NSSTS 2256_ LGQNT 2261_ STSSN 2266_ LQRTV 2271_ VTVGN 2276_ KNSHL 2281_ DGSSS 2286_ SEMKQ 2291_ SSASD 2296_ LVSKS 2301_ SSLKG 2306_ EKTKV 2311_ LSSKS 2316_ SEGSA 2321_ HNVAY 2326_ PGIPK 2331_ LAPQV 2336_ HNTTS 2341_ RELNV 2346_ SKIGS 2351_ FAEPS 2356_ SVSFS 2361_ SKEAL 2366_ SFPHL 2371_ HLRGQ 2376_ RNDRD 2381_ QHTDS 2386_ TQSAN 2391_ SSPDE 2396_ DTEVK 2401_ TLKLS 2406_ GMSNR 2411_ SSIIN 2416_ EHMGS 2421_ SSRDR 2426_ RQKGK 2431_ KSCKE 2436_ TFKEK 2441_ HSSKS 2446_ FLEPG 2451_ QVTTG 2456_ EEGNL 2461_ KPEFM 2466_ DEVLT 2471_ PEYMG 2476_ QRPCN 2481_ NVSSD 2486_ KIGDK 2491_ GLSMP 2496_ GVPKA 2501_ PPMQV 2506_ EGSAK 2511_ ELQAP 2516_ RKRTV 2521_ KVTLT 2526_ PLKME 2531_ NESQS 2536_ KNALK 2541_ ESSPA 2546_ SPLQI 2551_ ESTSP 2556_ TEPIS 2561_ ASENP 2566_ GDGPV 2571_ AQPSP 2576_ NNTSC 2581_ QDSQS 2586_ NNYQN 2591_ LPVQD 2596_ RNLML 2601_ PDGPK 2606_ PQEDG 2611_ SFKRR 2616_ YPRRS 2621_ ARARS 2626_ NMFFG 2631_ LTPLY 2636_ GVRSY 2641_ GEEDI 2646_ PFYSS 2651_ STGKK 2656_ RGKRS 2661_ AEGQV 2666_ DGADD 2671_ LSTSD 2676_ EDDLY 2681_ YYNFT 2686_ RTVIS 2691_ SGGEE 2696_ RLASH 2701_ NLFRE 2706_ EEQCD 2711_ LPKIS 2716_ QLDGV 2721_ DDGTE 2726_ SDTSV 2731_ TATTR 2736_ KSSQI 2741_ PKRNG 2746_ KENGT 2751_ ENLKI 2756_ DRPED 2761_ AGEKE 2766_ HVTKS 2771_ SVGHK 2776_ NEPKM 2781_ DNCHS 2786_ VSRVK 2791_ TQGQD 2796_ SLEAQ 2801_ LSSLE 2806_ SSRRV 2811_ HTSTP 2816_ SDKNL 2821_ LDTYN 2826_ TELLK 2831_ SDSDN 2836_ NNSDD 2841_ CGNIL 2846_ PSDIM 2851_ DFVLK 2856_ NTPSM 2861_ QALGE 2866_ SPESS 2871_ SSELL 2876_ NLGEG 2881_ LGLDS 2886_ NREKD 2891_ MGLFE 2896_ VFSQQ 2901_ LPTTE 2906_ PVDSS 2911_ VSSSI 2916_ SAEEQ 2921_ FELPL 2926_ ELPSD 2931_ LSVLT 2936_ TRSPT 2941_ VPSQN 2946_ PSRLA 2951_ VISDS 2956_ GEKRV 2961_ TITEK 2966_ SVASS 2971_ ESDPA 2976_ LLSPG 2981_ VDPTP 2986_ EGHMT 2991_ PDHFI 2996_ QGHMD 3001_ ADHIS 3006_ SPPCG 3011_ SVEQG 3016_ HGNNQ 3021_ DLTRN 3026_ SSTPG 3031_ LQVPV 3036_ SPTVP 3041_ IQNQK 3046_ YVPNS 3051_ TDSPG 3056_ PSQIS 3061_ NAAVQ 3066_ TTPPH 3071_ LKPAT 3076_ EKLIV 3081_ VNQNM 3086_ QPLYV 3091_ LQTLP 3096_ NGVTQ 3101_ KIQLT 3106_ SSVSS 3111_ TPSVM 3116_ ETNTS 3121_ VLGPM 3126_ GGGLT 3131_ LTTGL 3136_ NPSLP 3141_ TSQSL 3146_ FPSAS 3151_ KGLLP 3156_ MSHHQ 3161_ HLHSF 3166_ PAATQ 3171_ SSFPP 3176_ NISNP 3181_ PSGLL 3186_ IGVQP 3191_ PPDPQ 3196_ LLVSE 3201_ SSQRT 3206_ DLSTT 3211_ VATPS 3216_ SGLKK 3221_ RPISR 3226_ LQTRK 3231_ NKKLA 3236_ PSSTP 3241_ SNIAP 3246_ SDVVS 3251_ NMTLI 3256_ NFTPS 3261_ QLPNH 3266_ PSLLD 3271_ LGSLN 3276_ TSSHR 3281_ TVPNI 3286_ IKRSK 3291_ SSIMY 3296_ FEPAP 3301_ LLPQS 3306_ VGGTA 3311_ ATAAG 3316_ TSTIS 3321_ QDTSH 3326_ LTSGS 3331_ VSGLA 3336_ SSSSV 3341_ LNVVS 3346_ MQTTT 3351_ TPTSS 3356_ ASVPG 3361_ HVTLT 3366_ NPRLL 3371_ GTPDI 3376_ GSISN 3381_ LLIKA 3386_ SQQSL 3391_ GIQDQ 3396_ PVALP 3401_ PSSGM 3406_ FPQLG 3411_ TSQTP 3416_ STAAI 3421_ TAASS 3426_ ICVLP 3431_ STQTT 3436_ GITAA 3441_ SPSGE 3446_ ADEHY 3451_ QLQHV 3456_ NQLLA 3461_ SKTGI 3466_ HSSQR 3471_ DLDSA 3476_ SGPQV 3481_ SNFTQ 3486_ TVDAP 3491_ NSMGL 3496_ EQNKA 3501_ LSSAV 3506_ QASPT 3511_ SPGGS 3516_ PSSPS 3521_ SGQRS 3526_ ASPSV 3531_ PGPTK 3536_ PKPKT 3541_ KRFQL 3546_ PLDKG 3551_ NGKKH 3556_ KVSHL 3561_ RTSSS 3566_ EAHIP 3571_ DQETT 3576_ SLTSG 3581_ TGTPG 3586_ AEAEQ 3591_ QDTAS 3596_ VEQSS 3601_ QKECG 3606_ QPAGQ 3611_ VAVLP 3616_ EVQVT 3621_ QNPAN 3626_ EQESA 3631_ EPKTV 3636_ EEEES 3641_ NFSSP 3646_ LMLWL 3651_ QQEQK 3656_ RKESI 3661_ TEKKP 3666_ KKGLV 3671_ FEISS 3676_ DDGFQ 3681_ ICAES 3686_ IEDAW 3691_ KSLTD 3696_ KVQEA 3701_ RSNAR 3706_ LKQLS 3711_ FAGVN 3716_ GLRML 3721_ GILHD 3726_ AVVFL 3731_ IEQLS 3736_ GAKHC 3741_ RNYKF 3746_ RFHKP 3751_ EEANE 3756_ PPLNP 3761_ HGSAR 3766_ AEVHL 3771_ RKSAF 3776_ DMFNF 3781_ LASKH 3786_ RQPPE 3791_ YNPND 3796_ EEEEE 3801_ VQLKS 3806_ ARRAT 3811_ SMDLP 3816_ MPMRF 3821_ RHLKK 3826_ TSKEA 3831_ VGVYR 3836_ SPIHG 3841_ RGLFC 3846_ KRNID 3851_ AGEMV 3856_ IEYAG 3861_ NVIRS 3866_ IQTDK 3871_ REKYY 3876_ DSKGI 3881_ GCYMF 3886_ RIDDS 3891_ EVVDA 3896_ TMHGN 3901_ AARFI 3906_ NHSCE 3911_ PNCYS 3916_ RVINI 3921_ DGQKH 3926_ IVIFA 3931_ MRKIY 3936_ RGEEL 3941_ TYDYK 3946_ FPIED 3951_ ASNKL 3956_ PCNCG 3961_AKKCR
1: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145)