Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
1_MTSHY 6_ VIAIF 11_ ALMSS 16_ CLATA 21_ GPEPG 26_ ALCEL 31_ SPVSA 36_ SHPVQ 41_ ALMES 46_ FTVLS 51_ GCASR 56_ GTTGL 61_ PQEVH 66_ VLNLR 71_ TAGQG 76_ PGQLQ 81_ REVTL 86_ HLNPI 91_ SSVHI 96_ HHKSV 101_ VFLLN 106_ SPHPL 111_ VWHLK 116_ TERLA 121_ TGVSR 126_ LFLVS 131_ EGSVV 136_ QFSSA 141_ NFSLT 146_ AETEE 151_ RNFPH 156_ GNEHL 161_ LNWAR 166_ KEYGA 171_ VTSFT 176_ ELKIA 181_ RNIYI 186_ KVGED 191_ QVFPP 196_ KCNIG 201_ KNFLS 206_ LNYLA 211_ EYLQP 216_ KAAEG 221_ CVMSS 226_ QPQNE 231_ EVHII 236_ ELITP 241_ NSNPY 246_ SAFQV 251_ DITID 256_ IRPSQ 261_ EDLEV 266_ VKNLI 271_ LILKC 276_ KKSVN 281_ WVIKS 286_ FDVKG 291_ SLKII 296_ APNSI 301_ GFGKE 306_ SERSM 311_ TMTKS 316_ IRDDI 321_ PSTQG 326_ NLVKW 331_ ALDNG 336_ YSPIT 341_ SYTMA 346_ PVANR 351_ FHLRL 356_ ENNAE 361_ EMGDE 366_ EVHTI 371_ PPELR 376_ ILLDP 381_ GALPA 386_ LQNPP 391_ IRGGE 396_ GQNGG 401_ LPFPF 406_ PDISR 411_ RVWNE 416_ EGEDG 421_ LPRPK 426_ DPVIP 431_ SIQLF 436_ PGLRE 441_ PEEVQ 446_ GSVDI 451_ ALSVK 456_ CDNEK 461_ MIVAV 466_ EKDSF 471_ QASGY 476_ SGMDV 481_ TLLDP 486_ TCKAK 491_ MNGTH 496_ FVLES 501_ PLNGC 506_ GTRPR 511_ WSALD 516_ GVVYY 521_ NSIVI 526_ QVPAL 531_ GDSSG 536_ WPDGY 541_ EDLES 546_ GDNGF 551_ PGDMD 556_ EGDAS 561_ LFTRP 566_ EIVVF 571_ NCSLQ 576_ QVRNP 581_ SSFQE 586_ QPHGN 591_ ITFNM 596_ ELYNT 601_ DLFLV 606_ PSQGV 611_ FSVPE 616_ NGHVY 621_ VEVSV 626_ TKAEQ 631_ ELGFA 636_ IQTCF 641_ ISPYS 646_ NPDRM 651_ SHYTI 656_ IENIC 661_ PKDES 666_ VKFYS 671_ PKRVH 676_ FPIPQ 681_ ADMDK 686_ KRFSF 691_ VFKPV 696_ FNTSL 701_ LFLQC 706_ ELTLC 711_ TKMEK 716_ HPQKL 721_ PKCVP 726_ PDEAC 731_ TSLDA 736_ SIIWA 741_ MMQNK 746_ KTFTK 751_ PLAVI 756_ HHEAE 761_ SKEKG 766_ PSMKE 771_ PNPIS 776_ PPIFH 781_ GLDTL 786_ TVMGI 791_ AFAAF 796_ VIGAL 801_ LTGAL 806_ WYIYS 811_ HTGET 816_ AGRQQ 821_ VPTSP 826_ PASEN 831_ SSAAH 836_ SIGST 841_ QSTPC 846_SSSST
1: Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity)
2: (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL