Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
1_MEQPQ 6_ EEAPE 11_ VREEE 16_ EKEEV 21_ AEAEG 26_ APELN 31_ GGPQH 36_ ALPSS 41_ SYTDL 46_ SRSSS 51_ PPSLL 56_ DQLQM 61_ GCDGA 66_ SCGSL 71_ NMECR 76_ VCGDK 81_ ASGFH 86_ YGVHA 91_ CEGCK 96_ GFFRR 101_ TIRMK 106_ LEYEK 111_ CERSC 116_ KIQKK 121_ NRNKC 126_ QYCRF 131_ QKCLA 136_ LGMSH 141_ NAIRF 146_ GRMPE 151_ AEKRK 156_ LVAGL 161_ TANEG 166_ SQYNP 171_ QVADL 176_ KAFSK 181_ HIYNA 186_ YLKNF 191_ NMTKK 196_ KARSI 201_ LTGKA 206_ SHTAP 211_ FVIHD 216_ IETLW 221_ QAEKG 226_ LVWKQ 231_ LVNGL 236_ PPYKE 241_ ISVHV 246_ FYRCQ 251_ CTTVE 256_ TVREL 261_ TEFAK 266_ SIPSF 271_ SSLFL 276_ NDQVT 281_ LLKYG 286_ VHEAI 291_ FAMLA 296_ SIVNK 301_ DGLLV 306_ ANGSG 311_ FVTRE 316_ FLRSL 321_ RKPFS 326_ DIIEP 331_ KFEFA 336_ VKFNA 341_ LELDD 346_ SDLAL 351_ FIAAI 356_ ILCGD 361_ RPGLM 366_ NVPRV 371_ EAIQD 376_ TILRA 381_ LEFHL 386_ QANHP 391_ DAQYL 396_ FPKLL 401_ QKMAD 406_ LRQLV 411_ TEHAQ 416_ MMQRI 421_ KKTET 426_ ETSLH 431_ PLLQE 436_IYKDM
1: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand