AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1)
1_MAAPV 6_ KGNRK 11_ QSTEG 16_ DALDP 21_ PASPK 26_ PAGKQ 31_ NGIQN 36_ PISLE 41_ DSPEA 46_ GGERE 51_ EEQER 56_ EEEQA 61_ FLVSL 66_ YKFMK 71_ ERHTP 76_ IERVP 81_ HLGFK 86_ QINLW 91_ KIYKA 96_ VEKLG 101_ AYELV 106_ TGRRL 111_ WKNVY 116_ DELGG 121_ SPGST 126_ SAATC 131_ TRRHY 136_ ERLVL 141_ PYVRH 146_ LKGED 151_ DKPLP 156_ TSKPR 161_ KQYKM 166_ AKENR 171_ GDDGA 176_ TERPK 181_ KAKEE 186_ RRMDQ 191_ MMPGK 196_ TKADA 201_ ADPAP 206_ LPSQE 211_ PPRNS 216_ TEQQG 221_ LASGS 226_ SVSFV 231_ GASGC 236_ PEAYK 241_ RLLSS 246_ FYCKG 251_ THGIM 256_ SPLAK 261_ KKLLA 266_ QVSKV 271_ EALQC 276_ QEEGC 281_ RHGAE 286_ PQASP 291_ AVHLP 296_ ESPQS 301_ PKGLT 306_ ENSRH 311_ RLTPQ 316_ EGLQA 321_ PGGSL 326_ REEAQ 331_ AGPCP 336_ AAPIF 341_ KGCFY 346_ THPTE 351_ VLKPV 356_ SQHPR 361_ DFFSR 366_ LKDGV 371_ LLGPP 376_ GKEGL 381_ SVKEP 386_ QLVWG 391_ GDANR 396_ PSAFH 401_ KGGSR 406_ KGILY 411_ PKPKA 416_ CWVSP 421_ MAKVP 426_ AESPT 431_ LPPTF 436_ PSSPG 441_ LGSKR 446_ SLEEE 451_ GAAHS 456_ GKRLR 461_ AVSPF 466_ LKEAD 471_ AKKCG 476_ AKPAG 481_ SGLVS 486_ CLLGP 491_ ALGPV 496_ PPEAY 501_ RGTML 506_ HCPLN 511_ FTGTP 516_ GPLKG 521_ QAALP 526_ FSPLV 531_ IPAFP 536_ AHFLA 541_ TAGPS 546_ PMAAG 551_ LMHFP 556_ PTSFD 561_ SALRH 566_ RLCPA 571_ SSAWH 576_ APPVT 581_ TYAAP 586_HFFHL
1: DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA (PubMed:32209697). Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity)