UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)
1_MAELT 6_ ALESL 11_ IEMGF 16_ PRGRA 21_ EKALA 26_ LTGNQ 31_ GIEAA 36_ MDWLM 41_ EHEDD 46_ PDVDE 51_ PLETP 56_ LGHIL 61_ GREPT 66_ SSEQG 71_ GLEGS 76_ GSAAG 81_ EGKPA 86_ LSEEE 91_ RQEQT 96_ KRMLE 101_ LVAQK 106_ QRERE 111_ EREER 116_ EALER 121_ ERQRR 126_ RQGQE 131_ LSAAR 136_ QRLQE 141_ DEMRR 146_ AAEER 151_ RREKA 156_ EELAA 161_ RQRVR 166_ EKIER 171_ DKAER 176_ AKKYG 181_ GSVGS 186_ QPPPV 191_ APEPG 196_ PVPSS 201_ PSQEP 206_ PTKRE 211_ YDQCR 216_ IQVRL 221_ PDGTS 226_ LTQTF 231_ RAREQ 236_ LAAVR 241_ LYVEL 246_ HRGEE 251_ LGGGQ 256_ DPVQL 261_ LSGFP 266_ RRAFS 271_ EADME 276_ RPLQE 281_ LGLVP 286_ SAVLI 291_VAKKC
1: Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Also prevents the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol