Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase)
1_MWNLL 6_ HETDS 11_ AVATA 16_ RRPRW 21_ LCAGA 26_ LVLAG 31_ GFFLL 36_ GFLFG 41_ WFIKS 46_ SNEAT 51_ NITPK 56_ HNMKA 61_ FLDEL 66_ KAENI 71_ KKFLY 76_ NFTQI 81_ PHLAG 86_ TEQNF 91_ QLAKQ 96_ IQSQW 101_ KEFGL 106_ DSVEL 111_ AHYDV 116_ LLSYP 121_ NKTHP 126_ NYISI 131_ INEDG 136_ NEIFN 141_ TSLFE 146_ PPPPG 151_ YENVS 156_ DIVPP 161_ FSAFS 166_ PQGMP 171_ EGDLV 176_ YVNYA 181_ RTEDF 186_ FKLER 191_ DMKIN 196_ CSGKI 201_ VIARY 206_ GKVFR 211_ GNKVK 216_ NAQLA 221_ GAKGV 226_ ILYSD 231_ PADYF 236_ APGVK 241_ SYPDG 246_ WNLPG 251_ GGVQR 256_ GNILN 261_ LNGAG 266_ DPLTP 271_ GYPAN 276_ EYAYR 281_ RGIAE 286_ AVGLP 291_ SIPVH 296_ PIGYY 301_ DAQKL 306_ LEKMG 311_ GSAPP 316_ DSSWR 321_ GSLKV 326_ PYNVG 331_ PGFTG 336_ NFSTQ 341_ KVKMH 346_ IHSTN 351_ EVTRI 356_ YNVIG 361_ TLRGA 366_ VEPDR 371_ YVILG 376_ GHRDS 381_ WVFGG 386_ IDPQS 391_ GAAVV 396_ HEIVR 401_ SFGTL 406_ KKEGW 411_ RPRRT 416_ ILFAS 421_ WDAEE 426_ FGLLG 431_ STEWA 436_ EENSR 441_ LLQER 446_ GVAYI 451_ NADSS 456_ IEGNY 461_ TLRVD 466_ CTPLM 471_ YSLVH 476_ NLTKE 481_ LKSPD 486_ EGFEG 491_ KSLYE 496_ SWTKK 501_ SPSPE 506_ FSGMP 511_ RISKL 516_ GSGND 521_ FEVFF 526_ QRLGI 531_ ASGRA 536_ RYTKN 541_ WETNK 546_ FSGYP 551_ LYHSV 556_ YETYE 561_ LVEKF 566_ YDPMF 571_ KYHLT 576_ VAQVR 581_ GGMVF 586_ ELANS 591_ IVLPF 596_ DCRDY 601_ AVVLR 606_ KYADK 611_ IYSIS 616_ MKHPQ 621_ EMKTY 626_ SVSFD 631_ SLFSA 636_ VKNFT 641_ EIASK 646_ FSERL 651_ QDFDK 656_ SNPIV 661_ LRMMN 666_ DQLMF 671_ LERAF 676_ IDPLG 681_ LPDRP 686_ FYRHV 691_ IYAPS 696_ SHNKY 701_ AGESF 706_ PGIYD 711_ ALFDI 716_ ESKVD 721_ PSKAW 726_ GEVKR 731_ QIYVA 736_ AFTVQ 741_AAAET
1: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression
2: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC