Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)
1_MNKAP 6_ QSTGP 11_ PPAPS 16_ PGLPQ 21_ PAFPP 26_ GQTAP 31_ VVFST 36_ PQATQ 41_ MNTPS 46_ QPRQH 51_ FYPSR 56_ AQPPS 61_ SAASR 66_ VQSAA 71_ PARPG 76_ PAAHV 81_ YPAGS 86_ QVMMI 91_ PSQIS 96_ YPASQ 101_ GAYYI 106_ PGQGR 111_ STYVV 116_ PTQQY 121_ PVQPG 126_ APGFY 131_ PGASP 136_ TEFGT 141_ YAGAY 146_ YPAQG 151_ VQQFP 156_ TGVAP 161_ TPVLM 166_ NQPPQ 171_ IAPKR 176_ ERKTI 181_ RIRDP 186_ NQGGK 191_ DITEE 196_ IMSGA 201_ RTAST 206_ PTPPQ 211_ TGGGL 216_ EPQAN 221_ GETPQ 226_ VAVIV 231_ RPDDR 236_ SQGAI 241_ IADRP 246_ GLPGP 251_ EHSPS 256_ ESQPS 261_ SPSPT 266_ PSPSP 271_ VLEPG 276_ SEPNL 281_ AVLSI 286_ PGDTM 291_ TTIQM 296_ SVEES 301_ TPISR 306_ ETGEP 311_ YRLSP 316_ EPTPL 321_ AEPIL 326_ EVEVT 331_ LSKPV 336_ PESEF 341_ SSSPL 346_ QAPTP 351_ LASHT 356_ VEIHE 361_ PNGMV 366_ PSEDL 371_ EPEVE 376_ SSPEL 381_ APPPA 386_ CPSES 391_ PVPIA 396_ PTAQP 401_ EELLN 406_ GAPSP 411_ PAVDL 416_ SPVSE 421_ PEEQA 426_ KEVTA 431_ SMAPP 436_ TIPSA 441_ TPATA 446_ PSATS 451_ PAQEE 456_ EMEEE 461_ EEEEE 466_ GEAGE 471_ AGEAE 476_ SEKGG 481_ EELLP 486_ PESTP 491_ IPANL 496_ SQNLE 501_ AAAAT 506_ QVAVS 511_ VPKRR 516_ RKIKE 521_ LNKKE 526_ AVGDL 531_ LDAFK 536_ EANPA 541_ VPEVE 546_ NQPPA 551_ GSNPG 556_ PESEG 561_ SGVPP 566_ RPEEA 571_ DETWD 576_ SKEDK 581_ IHNAE 586_ NIQPG 591_ EQKYE 596_ YKSDQ 601_ WKPLN 606_ LEEKK 611_ RYDRE 616_ FLLGF 621_ QFIFA 626_ SMQKP 631_ EGLPH 636_ ISDVV 641_ LDKAN 646_ KTPLR 651_ PLDPT 656_ RLQGI 661_ NCGPD 666_ FTPSF 671_ ANLGR 676_ TTLST 681_ RGPPR 686_ GGPGG 691_ ELPRG 696_ PAGLG 701_ PRRSQ 706_ QGPRK 711_ EPRKI 716_ IATVL 721_ MTEDI 726_ KLNKA 731_ EKAWK 736_ PSSKR 741_ TAADK 746_ DRGEE 751_ DADGS 756_ KTQDL 761_ FRRVR 766_ SILNK 771_ LTPQM 776_ FQQLM 781_ KQVTQ 786_ LAIDT 791_ EERLK 796_ GVIDL 801_ IFEKA 806_ ISEPN 811_ FSVAY 816_ ANMCR 821_ CLMAL 826_ KVPTT 831_ EKPTV 836_ TVNFR 841_ KLLLN 846_ RCQKE 851_ FEKDK 856_ DDDEV 861_ FEKKQ 866_ KEMDE 871_ AATAE 876_ ERGRL 881_ KEELE 886_ EARDI 891_ ARRRS 896_ LGNIK 901_ FIGEL 906_ FKLKM 911_ LTEAI 916_ MHDCV 921_ VKLLK 926_ NHDEE 931_ SLECL 936_ CRLLT 941_ TIGKD 946_ LDFEK 951_ AKPRM 956_ DQYFN 961_ QMEKI 966_ IKEKK 971_ TSSRI 976_ RFMLQ 981_ DVLDL 986_ RGSNW 991_ VPRRG 996_ DQGPK 1001_ TIDQI 1006_ HKEAE 1011_ MEEHR 1016_ EHIKV 1021_ QQLMA 1026_ KGSDK 1031_ RRGGP 1036_ PGPPI 1041_ SRGLP 1046_ LVDDG 1051_ GWNTV 1056_ PISKG 1061_ SRPID 1066_ TSRLT 1071_ KITKP 1076_ GSIDS 1081_ NNQLF 1086_ APGGR 1091_ LSWGK 1096_ GSSGG 1101_ SGAKP 1106_ SDAAS 1111_ EAARP 1116_ ATSTL 1121_ NRFSA 1126_ LQQAV 1131_ PTEST 1136_ DNRRV 1141_ VQRSS 1146_ LSRER 1151_ GEKAG 1156_ DRGDR 1161_ LERSE 1166_ RGGDR 1171_ GDRLD 1176_ RARTP 1181_ ATKRS 1186_ FSKEV 1191_ EERSR 1196_ ERPSQ 1201_ PEGLR 1206_ KAASL 1211_ TEDRD 1216_ RGRDA 1221_ VKREA 1226_ ALPPV 1231_ SPLKA 1236_ ALSEE 1241_ ELEKK 1246_ SKAII 1251_ EEYLH 1256_ LNDMK 1261_ EAVQC 1266_ VQELA 1271_ SPSLL 1276_ FIFVR 1281_ HGVES 1286_ TLERS 1291_ AIARE 1296_ HMGQL 1301_ LHQLL 1306_ CAGHL 1311_ STAQY 1316_ YQGLY 1321_ EILEL 1326_ AEDME 1331_ IDIPH 1336_ VWLYL 1341_ AELVT 1346_ PILQE 1351_ GGVPM 1356_ GELFR 1361_ EITKP 1366_ LRPLG 1371_ KAASL 1376_ LLEIL 1381_ GLLCK 1386_ SMGPK 1391_ KVGTL 1396_ WREAG 1401_ LSWKE 1406_ FLPEG 1411_ QDIGA 1416_ FVAEQ 1421_ KVEYT 1426_ LGEES 1431_ EAPGQ 1436_ RALPS 1441_ EELNR 1446_ QLEKL 1451_ LKEGS 1456_ SNQRV 1461_ FDWIE 1466_ ANLSE 1471_ QQIVS 1476_ NTLVR 1481_ ALMTA 1486_ VCYSA 1491_ IIFET 1496_ PLRVD 1501_ VAVLK 1506_ ARAKL 1511_ LQKYL 1516_ CDEQK 1521_ ELQAL 1526_ YALQA 1531_ LVVTL 1536_ EQPPN 1541_ LLRMF 1546_ FDALY 1551_ DEDVV 1556_ KEDAF 1561_ YSWES 1566_ SKDPA 1571_ EQQGK 1576_ GVALK 1581_ SVTAF 1586_ FKWLR 1591_EAEEE
1: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139)