Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
1_MPALR 6_ PALLW 11_ ALLAL 16_ WLCCA 21_ APAHA 26_ LQCRD 31_ GYEPC 36_ VNEGM 41_ CVTYH 46_ NGTGY 51_ CKCPE 56_ GFLGE 61_ YCQHR 66_ DPCEK 71_ NRCQN 76_ GGTCV 81_ AQAML 86_ GKATC 91_ RCASG 96_ FTGED 101_ CQYST 106_ SHPCF 111_ VSRPC 116_ LNGGT 121_ CHMLS 126_ RDTYE 131_ CTCQV 136_ GFTGK 141_ ECQWT 146_ DACLS 151_ HPCAN 156_ GSTCT 161_ TVANQ 166_ FSCKC 171_ LTGFT 176_ GQKCE 181_ TDVNE 186_ CDIPG 191_ HCQHG 196_ GTCLN 201_ LPGSY 206_ QCQCP 211_ QGFTG 216_ QYCDS 221_ LYVPC 226_ APSPC 231_ VNGGT 236_ CRQTG 241_ DFTFE 246_ CNCLP 251_ GFEGS 256_ TCERN 261_ IDDCP 266_ NHRCQ 271_ NGGVC 276_ VDGVN 281_ TYNCR 286_ CPPQW 291_ TGQFC 296_ TEDVD 301_ ECLLQ 306_ PNACQ 311_ NGGTC 316_ ANRNG 321_ GYGCV 326_ CVNGW 331_ SGDDC 336_ SENID 341_ DCAFA 346_ SCTPG 351_ STCID 356_ RVASF 361_ SCMCP 366_ EGKAG 371_ LLCHL 376_ DDACI 381_ SNPCH 386_ KGALC 391_ DTNPL 396_ NGQYI 401_ CTCPQ 406_ GYKGA 411_ DCTED 416_ VDECA 421_ MANSN 426_ PCEHA 431_ GKCVN 436_ TDGAF 441_ HCECL 446_ KGYAG 451_ PRCEM 456_ DINEC 461_ HSDPC 466_ QNDAT 471_ CLDKI 476_ GGFTC 481_ LCMPG 486_ FKGVH 491_ CELEI 496_ NECQS 501_ NPCVN 506_ NGQCV 511_ DKVNR 516_ FQCLC 521_ PPGFT 526_ GPVCQ 531_ IDIDD 536_ CSSTP 541_ CLNGA 546_ KCIDH 551_ PNGYE 556_ CQCAT 561_ GFTGV 566_ LCEEN 571_ IDNCD 576_ PDPCH 581_ HGQCQ 586_ DGIDS 591_ YTCIC 596_ NPGYM 601_ GAICS 606_ DQIDE 611_ CYSSP 616_ CLNDG 621_ RCIDL 626_ VNGYQ 631_ CNCQP 636_ GTSGV 641_ NCEIN 646_ FDDCA 651_ SNPCI 656_ HGICM 661_ DGINR 666_ YSCVC 671_ SPGFT 676_ GQRCN 681_ IDIDE 686_ CASNP 691_ CRKGA 696_ TCING 701_ VNGFR 706_ CICPE 711_ GPHHP 716_ SCYSQ 721_ VNECL 726_ SNPCI 731_ HGNCT 736_ GGLSG 741_ YKCLC 746_ DAGWV 751_ GINCE 756_ VDKNE 761_ CLSNP 766_ CQNGG 771_ TCDNL 776_ VNGYR 781_ CTCKK 786_ GFKGY 791_ NCQVN 796_ IDECA 801_ SNPCL 806_ NQGTC 811_ FDDIS 816_ GYTCH 821_ CVLPY 826_ TGKNC 831_ QTVLA 836_ PCSPN 841_ PCENA 846_ AVCKE 851_ SPNFE 856_ SYTCL 861_ CAPGW 866_ QGQRC 871_ TIDID 876_ ECISK 881_ PCMNH 886_ GLCHN 891_ TQGSY 896_ MCECP 901_ PGFSG 906_ MDCEE 911_ DIDDC 916_ LANPC 921_ QNGGS 926_ CMDGV 931_ NTFSC 936_ LCLPG 941_ FTGDK 946_ CQTDM 951_ NECLS 956_ EPCKN 961_ GGTCS 966_ DYVNS 971_ YTCKC 976_ QAGFD 981_ GVHCE 986_ NNINE 991_ CTESS 996_ CFNGG 1001_ TCVDG 1006_ INSFS 1011_ CLCPV 1016_ GFTGS 1021_ FCLHE 1026_ INECS 1031_ SHPCL 1036_ NEGTC 1041_ VDGLG 1046_ TYRCS 1051_ CPLGY 1056_ TGKNC 1061_ QTLVN 1066_ LCSRS 1071_ PCKNK 1076_ GTCVQ 1081_ KKAES 1086_ QCLCP 1091_ SGWAG 1096_ AYCDV 1101_ PNVSC 1106_ DIAAS 1111_ RRGVL 1116_ VEHLC 1121_ QHSGV 1126_ CINAG 1131_ NTHYC 1136_ QCPLG 1141_ YTGSY 1146_ CEEQL 1151_ DECAS 1156_ NPCQH 1161_ GATCS 1166_ DFIGG 1171_ YRCEC 1176_ VPGYQ 1181_ GVNCE 1186_ YEVDE 1191_ CQNQP 1196_ CQNGG 1201_ TCIDL 1206_ VNHFK 1211_ CSCPP 1216_ GTRGL 1221_ LCEEN 1226_ IDDCA 1231_ RGPHC 1236_ LNGGQ 1241_ CMDRI 1246_ GGYSC 1251_ RCLPG 1256_ FAGER 1261_ CEGDI 1266_ NECLS 1271_ NPCSS 1276_ EGSLD 1281_ CIQLT 1286_ NDYLC 1291_ VCRSA 1296_ FTGRH 1301_ CETFV 1306_ DVCPQ 1311_ MPCLN 1316_ GGTCA 1321_ VASNM 1326_ PDGFI 1331_ CRCPP 1336_ GFSGA 1341_ RCQSS 1346_ CGQVK 1351_ CRKGE 1356_ QCVHT 1361_ ASGPR 1366_ CFCPS 1371_ PRDCE 1376_ SGCAS 1381_ SPCQH 1386_ GGSCH 1391_ PQRQP 1396_ PYYSC 1401_ QCAPP 1406_ FSGSR 1411_ CELYT 1416_ APPST 1421_ PPATC 1426_ LSQYC 1431_ ADKAR 1436_ DGVCD 1441_ EACNS 1446_ HACQW 1451_ DGGDC 1456_ SLTME 1461_ NPWAN 1466_ CSSPL 1471_ PCWDY 1476_ INNQC 1481_ DELCN 1486_ TVECL 1491_ FDNFE 1496_ CQGNS 1501_ KTCKY 1506_ DKYCA 1511_ DHFKD 1516_ NHCDQ 1521_ GCNSE 1526_ ECGWD 1531_ GLDCA 1536_ ADQPE 1541_ NLAEG 1546_ TLVIV 1551_ VLMPP 1556_ EQLLQ 1561_ DARSF 1566_ LRALG 1571_ TLLHT 1576_ NLRIK 1581_ RDSQG 1586_ ELMVY 1591_ PYYGE 1596_ KSAAM 1601_ KKQRM 1606_ TRRSL 1611_ PGEQE 1616_ QEVAG 1621_ SKVFL 1626_ EIDNR 1631_ QCVQD 1636_ SDHCF 1641_ KNTDA 1646_ AAALL 1651_ ASHAI 1656_ QGTLS 1661_ YPLVS 1666_ VVSES 1671_ LTPER 1676_ TQLLY 1681_ LLAVA 1686_ VVIIL 1691_ FIILL 1696_ GVIMA 1701_ KRKRK 1706_ HGSLW 1711_ LPEGF 1716_ TLRRD 1721_ ASNHK 1726_ RREPV 1731_ GQDAV 1736_ GLKNL 1741_ SVQVS 1746_ EANLI 1751_ GTGTS 1756_ EHWVD 1761_ DEGPQ 1766_ PKKVK 1771_ AEDEA 1776_ LLSEE 1781_ DDPID 1786_ RRPWT 1791_ QQHLE 1796_ AADIR 1801_ RTPSL 1806_ ALTPP 1811_ QAEQE 1816_ VDVLD 1821_ VNVRG 1826_ PDGCT 1831_ PLMLA 1836_ SLRGG 1841_ SSDLS 1846_ DEDED 1851_ AEDSS 1856_ ANIIT 1861_ DLVYQ 1866_ GASLQ 1871_ AQTDR 1876_ TGEMA 1881_ LHLAA 1886_ RYSRA 1891_ DAAKR 1896_ LLDAG 1901_ ADANA 1906_ QDNMG 1911_ RCPLH 1916_ AAVAA 1921_ DAQGV 1926_ FQILI 1931_ RNRVT 1936_ DLDAR 1941_ MNDGT 1946_ TPLIL 1951_ AARLA 1956_ VEGMV 1961_ AELIN 1966_ CQADV 1971_ NAVDD 1976_ HGKSA 1981_ LHWAA 1986_ AVNNV 1991_ EATLL 1996_ LLKNG 2001_ ANRDM 2006_ QDNKE 2011_ ETPLF 2016_ LAARE 2021_ GSYEA 2026_ AKILL 2031_ DHFAN 2036_ RDITD 2041_ HMDRL 2046_ PRDVA 2051_ RDRMH 2056_ HDIVR 2061_ LLDEY 2066_ NVTPS 2071_ PPGTV 2076_ LTSAL 2081_ SPVIC 2086_ GPNRS 2091_ FLSLK 2096_ HTPMG 2101_ KKSRR 2106_ PSAKS 2111_ TMPTS 2116_ LPNLA 2121_ KEAKD 2126_ AKGSR 2131_ RKKSL 2136_ SEKVQ 2141_ LSESS 2146_ VTLSP 2151_ VDSLE 2156_ SPHTY 2161_ VSDTT 2166_ SSPMI 2171_ TSPGI 2176_ LQASP 2181_ NPMLA 2186_ TAAPP 2191_ APVHA 2196_ QHALS 2201_ FSNLH 2206_ EMQPL 2211_ AHGAS 2216_ TVLPS 2221_ VSQLL 2226_ SHHHI 2231_ VSPGS 2236_ GSAGS 2241_ LSRLH 2246_ PVPVP 2251_ ADWMN 2256_ RMEVN 2261_ ETQYN 2266_ EMFGM 2271_ VLAPA 2276_ EGTHP 2281_ GIAPQ 2286_ SRPPE 2291_ GKHIT 2296_ TPREP 2301_ LPPIV 2306_ TFQLI 2311_ PKGSI 2316_ AQPAG 2321_ APQPQ 2326_ STCPP 2331_ AVAGP 2336_ LPTMY 2341_ QIPEM 2346_ ARLPS 2351_ VAFPT 2356_ AMMPQ 2361_ QDGQV 2366_ AQTIL 2371_ PAYHP 2376_ FPASV 2381_ GKYPT 2386_ PPSQH 2391_ SYASS 2396_ NAAER 2401_ TPSHS 2406_ GHLQG 2411_ EHPYL 2416_ TPSPE 2421_ SPDQW 2426_ SSSSP 2431_ HSASD 2436_ WSDVT 2441_ TSPTP 2446_ GGAGG 2451_ GQRGP 2456_ GTHMS 2461_ EPPHN 2466_NMQVY
1: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737)