Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)
1_MAEPQ 6_ PPSGG 11_ LTDEA 16_ ALSCC 21_ SDADP 26_ STKDF 31_ LLQQT 36_ MLRVK 41_ DPKKS 46_ LDFYT 51_ RVLGM 56_ TLIQK 61_ CDFPI 66_ MKFSL 71_ YFLAY 76_ EDKND 81_ IPKEK 86_ DEKIA 91_ WALSR 96_ KATLE 101_ LTHNW 106_ GTEDD 111_ ETQSY 116_ HNGNS 121_ DPRGF 126_ GHIGI 131_ AVPDV 136_ YSACK 141_ RFEEL 146_ GVKFV 151_ KKPDD 156_ GKMKG 161_ LAFIQ 166_ DPDGY 171_ WIEIL 176_NPNKM
1: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity)