Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
1_MVDGV 6_ MILPV 11_ LIMIA 16_ LPSPS 21_ MEDEK 26_ PKVNP 31_ KLYMC 36_ VCEGL 41_ SCGNE 46_ DHCEG 51_ QQCFS 56_ SLSIN 61_ DGFHV 66_ YQKGC 71_ FQVYE 76_ QGKMT 81_ CKTPP 86_ SPGQA 91_ VECCQ 96_ GDWCN 101_ RNITA 106_ QLPTK 111_ GKSFP 116_ GTQNF 121_ HLEVG 126_ LIILS 131_ VVFAV 136_ CLLAC 141_ LLGVA 146_ LRKFK 151_ RRNQE 156_ RLNPR 161_ DVEYG 166_ TIEGL 171_ ITTNV 176_ GDSTL 181_ ADLLD 186_ HSCTS 191_ GSGSG 196_ LPFLV 201_ QRTVA 206_ RQITL 211_ LECVG 216_ KGRYG 221_ EVWRG 226_ SWQGE 231_ NVAVK 236_ IFSSR 241_ DEKSW 246_ FRETE 251_ LYNTV 256_ MLRHE 261_ NILGF 266_ IASDM 271_ TSRHS 276_ STQLW 281_ LITHY 286_ HEMGS 291_ LYDYL 296_ QLTTL 301_ DTVSC 306_ LRIVL 311_ SIASG 316_ LAHLH 321_ IEIFG 326_ TQGKP 331_ AIAHR 336_ DLKSK 341_ NILVK 346_ KNGQC 351_ CIADL 356_ GLAVM 361_ HSQST 366_ NQLDV 371_ GNNPR 376_ VGTKR 381_ YMAPE 386_ VLDET 391_ IQVDC 396_ FDSYK 401_ RVDIW 406_ AFGLV 411_ LWEVA 416_ RRMVS 421_ NGIVE 426_ DYKPP 431_ FYDVV 436_ PNDPS 441_ FEDMR 446_ KVVCV 451_ DQQRP 456_ NIPNR 461_ WFSDP 466_ TLTSL 471_ AKLMK 476_ ECWYQ 481_ NPSAR 486_ LTALR 491_ IKKTL 496_ TKIDN 501_SLDKL
1: Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed:25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed:9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed:17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity)