Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB)
1_MDSKY 6_ QCVKL 11_ NDGHF 16_ MPVLG 21_ FGTYA 26_ PAEVP 31_ KSKAL 36_ EATKL 41_ AIEAG 46_ FRHID 51_ SAHLY 56_ NNEEQ 61_ VGLAI 66_ RSKIA 71_ DGSVK 76_ REDIF 81_ YTSKL 86_ WCNSH 91_ RPELV 96_ RPALE 101_ RSLKN 106_ LQLDY 111_ VDLYL 116_ IHFPV 121_ SVKPG 126_ EEVIP 131_ KDENG 136_ KILFD 141_ TVDLC 146_ ATWEA 151_ VEKCK 156_ DAGLA 161_ KSIGV 166_ SNFNR 171_ RQLEM 176_ ILNKP 181_ GLKYK 186_ PVCNQ 191_ VECHP 196_ YFNQR 201_ KLLDF 206_ CKSKD 211_ IVLVA 216_ YSALG 221_ SHREE 226_ PWVDP 231_ NSPVL 236_ LEDPV 241_ LCALA 246_ KKHKR 251_ TPALI 256_ ALRYQ 261_ LQRGV 266_ VVLAK 271_ SYNEQ 276_ RIRQN 281_ VQVFE 286_ FQLTS 291_ EEMKA 296_ IDGLN 301_ RNVRY 306_ LTLDI 311_ FAGPP 316_NYPFS
1: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699)