Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
1_MELLP 6_ PLPQS 11_ FLLLL 16_ LLPAK 21_ PAAGE 26_ DWQCP 31_ RTPYA 36_ ASRDF 41_ DVKYV 46_ VPSFS 51_ AGGLV 56_ QAMVT 61_ YEGDR 66_ NESAV 71_ FVAIR 76_ NRLHV 81_ LGPDL 86_ KSVQS 91_ LATGP 96_ AGDPG 101_ CQTCA 106_ ACGPG 111_ PHGPP 116_ GDTDT 121_ KVLVL 126_ DPALP 131_ ALVSC 136_ GSSLQ 141_ GRCFL 146_ HDLEP 151_ QGTAV 156_ HLAAP 161_ ACLFS 166_ AHHNR 171_ PDDCP 176_ DCVAS 181_ PLGTR 186_ VTVVE 191_ QGQAS 196_ YFYVA 201_ SSLDA 206_ AVAAS 211_ FSPRS 216_ VSIRR 221_ LKADA 226_ SGFAP 231_ GFVAL 236_ SVLPK 241_ HLVSY 246_ SIEYV 251_ HSFHT 256_ GAFVY 261_ FLTVQ 266_ PASVT 271_ DDPSA 276_ LHTRL 281_ ARLSA 286_ TEPEL 291_ GDYRE 296_ LVLDC 301_ RFAPK 306_ RRRRG 311_ APEGG 316_ QPYPV 321_ LRVAH 326_ SAPVG 331_ AQLAT 336_ ELSIA 341_ EGQEV 346_ LFGVF 351_ VTGKD 356_ GGPGV 361_ GPNSV 366_ VCAFP 371_ IDLLD 376_ TLIDE 381_ GVERC 386_ CESPV 391_ HPGLR 396_ RGLDF 401_ FQSPS 406_ FCPNP 411_ PGLEA 416_ LSPNT 421_ SCRHF 426_ PLLVS 431_ SSFSR 436_ VDLFN 441_ GLLGP 446_ VQVTA 451_ LYVTR 456_ LDNVT 461_ VAHMG 466_ TMDGR 471_ ILQVE 476_ LVRSL 481_ NYLLY 486_ VSNFS 491_ LGDSG 496_ QPVQR 501_ DVSRL 506_ GDHLL 511_ FASGD 516_ QVFQV 521_ PIQGP 526_ GCRHF 531_ LTCGR 536_ CLRAW 541_ HFMGC 546_ GWCGN 551_ MCGQQ 556_ KECPG 561_ SWQQD 566_ HCPPK 571_ LTEFH 576_ PHSGP 581_ LRGST 586_ RLTLC 591_ GSNFY 596_ LHPSG 601_ LVPEG 606_ THQVT 611_ VGQSP 616_ CRPLP 621_ KDSSK 626_ LRPVP 631_ RKDFV 636_ EEFEC 641_ ELEPL 646_ GTQAV 651_ GPTNV 656_ SLTVT 661_ NMPPG 666_ KHFRV 671_ DGTSV 676_ LRGFS 681_ FMEPV 686_ LIAVQ 691_ PLFGP 696_ RAGGT 701_ CLTLE 706_ GQSLS 711_ VGTSR 716_ AVLVN 721_ GTECL 726_ LARVS 731_ EGQLL 736_ CATPP 741_ GATVA 746_ SVPLS 751_ LQVGG 756_ AQVPG 761_ SWTFQ 766_ YREDP 771_ VVLSI 776_ SPNCG 781_ YINSH 786_ ITICG 791_ QHLTS 796_ AWHLV 801_ LSFHD 806_ GLRAV 811_ ESRCE 816_ RQLPE 821_ QQLCR 826_ LPEYV 831_ VRDPQ 836_ GWVAG 841_ NLSAR 846_ GDGAA 851_ GFTLP 856_ GFRFL 861_ PPPHP 866_ PSANL 871_ VPLKP 876_ EEHAI 881_ KFEYI 886_ GLGAV 891_ ADCVG 896_ INVTV 901_ GGESC 906_ QHEFR 911_ GDMVV 916_ CPLPP 921_ SLQLG 926_ QDGAP 931_ LQVCV 936_ DGECH 941_ ILGRV 946_ VRPGP 951_ DGVPQ 956_ STLLG 961_ ILLPL 966_ LLLVA 971_ ALATA 976_ LVFSY 981_ WWRRK 986_ QLVLP 991_ PNLND 996_ LASLD 1001_ QTAGA 1006_ TPLPI 1011_ LYSGS 1016_ DYRSG 1021_ LALPA 1026_ IDGLD 1031_ STTCV 1036_ HGASF 1041_ SDSED 1046_ ESCVP 1051_ LLRKE 1056_ SIQLR 1061_ DLDSA 1066_ LLAEV 1071_ KDVLI 1076_ PHERV 1081_ VTHSD 1086_ RVIGK 1091_ GHFGV 1096_ VYHGE 1101_ YIDQA 1106_ QNRIQ 1111_ CAIKS 1116_ LSRIT 1121_ EMQQV 1126_ EAFLR 1131_ EGLLM 1136_ RGLNH 1141_ PNVLA 1146_ LIGIM 1151_ LPPEG 1156_ LPHVL 1161_ LPYMC 1166_ HGDLL 1171_ QFIRS 1176_ PQRNP 1181_ TVKDL 1186_ ISFGL 1191_ QVARG 1196_ MEYLA 1201_ EQKFV 1206_ HRDLA 1211_ ARNCM 1216_ LDESF 1221_ TVKVA 1226_ DFGLA 1231_ RDILD 1236_ REYYS 1241_ VQQHR 1246_ HARLP 1251_ VKWMA 1256_ LESLQ 1261_ TYRFT 1266_ TKSDV 1271_ WSFGV 1276_ LLWEL 1281_ LTRGA 1286_ PPYRH 1291_ IDPFD 1296_ LTHFL 1301_ AQGRR 1306_ LPQPE 1311_ YCPDS 1316_ LYQVM 1321_ QQCWE 1326_ ADPAV 1331_ RPTFR 1336_ VLVGE 1341_ VEQIV 1346_ SALLG 1351_ DHYVQ 1356_ LPATY 1361_ MNLGP 1366_ STSHE 1371_ MNVRP 1376_ EQPQF 1381_ SPMPG 1386_ NVRRP 1391_RPLSE
1: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand