Sex-determining region Y protein (Testis-determining factor)
1_MQSYA 6_ SAMLS 11_ VFNSD 16_ DYSPA 21_ VQENI 26_ PALRR 31_ SSSFL 36_ CTESC 41_ NSKYQ 46_ CETGE 51_ NSKGN 56_ VQDRV 61_ KRPMN 66_ AFIVW 71_ SRDQR 76_ RKMAL 81_ ENPRM 86_ RNSEI 91_ SKQLG 96_ YQWKM 101_ LTEAE 106_ KWPFF 111_ QEAQK 116_ LQAMH 121_ REKYP 126_ NYKYR 131_ PRRKA 136_ KMLPK 141_ NCSLL 146_ PADPA 151_ SVLCS 156_ EVQLD 161_ NRLYR 166_ DDCTK 171_ ATHSR 176_ MEHQL 181_ GHLPP 186_ INAAS 191_ SPQQR 196_DRYSH
1: Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16414182, PubMed:16996051). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:11563911, PubMed:1425584, PubMed:15170344, PubMed:8159753, PubMed:8265659). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:11563911, PubMed:1425584, PubMed:15170344, PubMed:16762365, PubMed:8159753, PubMed:8265659). Also involved in pre-mRNA splicing (PubMed:11818535). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity)