Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
1_MEKLH 6_ QCYWK 11_ SGEPQ 16_ SDDIE 21_ ASRMK 26_ RAAAK 31_ HLIER 36_ YYHQL 41_ TEGCG 46_ NEACT 51_ NEFCA 56_ SCPTF 61_ LRMDN 66_ NAAAI 71_ KALEL 76_ YKINA 81_ KLCDP 86_ HPSKK 91_ GASSA 96_ YLENS 101_ KGAPN 106_ NSCSE 111_ IKMNK 116_ KGARI 121_ DFKDV 126_ TYLTE 131_ EKVYE 136_ ILELC 141_ RERED 146_ YSPLI 151_ RVIGR 156_ VFSSA 161_ EALVQ 166_ SFRKV 171_ KQHTK 176_ EELKS 181_ LQAKD 186_ EDKDE 191_ DEKEK 196_ AACSA 201_ AAMEE 206_ DSEAS 211_ SSRIG 216_ DSSQG 221_ DNNLQ 226_ KLGPD 231_ DVSVD 236_ IDAIR 241_ RVYTR 246_ LLSNE 251_ KIETA 256_ FLNAL 261_ VYLSP 266_ NVECD 271_ LTYHN 276_ VYSRD 281_ PNYLN 286_ LFIIV 291_ MENRN 296_ LHSPE 301_ YLEMA 306_ LPLFC 311_ KAMSK 316_ LPLAA 321_ QGKLI 326_ RLWSK 331_ YNADQ 336_ IRRMM 341_ ETFQQ 346_ LITYK 351_ VISNE 356_ FNSRN 361_ LVNDD 366_ DAIVA 371_ ASKCL 376_ KMVYY 381_ ANVVG 386_ GEVDT 391_ NHNEE 396_ DDEEP 401_ IPESS 406_ ELTLQ 411_ ELLGE 416_ ERRNK 421_ KGPRV 426_ DPLET 431_ ELGVK 436_ TLDCR 441_ KPLIP 446_ FEEFI 451_ NEPLN 456_ EVLEM 461_ DKDYT 466_ FFKVE 471_ TENKF 476_ SFMTC 481_ PFILN 486_ AVTKN 491_ LGLYY 496_ DNRIR 501_ MYSER 506_ RITVL 511_ YSLVQ 516_ GQQLN 521_ PYLRL 526_ KVRRD 531_ HIIDD 536_ ALVRL 541_ EMIAM 546_ ENPAD 551_ LKKQL 556_ YVEFE 561_ GEQGV 566_ DEGGV 571_ SKEFF 576_ QLVVE 581_ EIFNP 586_ DIGMF 591_ TYDES 596_ TKLFW 601_ FNPSS 606_ FETEG 611_ QFTLI 616_ GIVLG 621_ LAIYN 626_ NCILD 631_ VHFPM 636_ VVYRK 641_ LMGKK 646_ GTFRD 651_ LGDSH 656_ PVLYQ 661_ SLKDL 666_ LEYEG 671_ NVEDD 676_ MMITF 681_ QISQT 686_ DLFGN 691_ PMMYD 696_ LKENG 701_ DKIPI 706_ TNENR 711_ KEFVN 716_ LYSDY 721_ ILNKS 726_ VEKQF 731_ KAFRR 736_ GFHMV 741_ TNESP 746_ LKYLF 751_ RPEEI 756_ ELLIC 761_ GSRNL 766_ DFQAL 771_ EETTE 776_ YDGGY 781_ TRDSV 786_ LIREF 791_ WEIVH 796_ SFTDE 801_ QKRLF 806_ LQFTT 811_ GTDRA 816_ PVGGL 821_ GKLKM 826_ IIAKN 831_ GPDTE 836_ RLPTS 841_ HTCFN 846_ VLLLP 851_ EYSSK 856_ EKLKE 861_ RLLKA 866_ITYAK
1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533)
2: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses