Dynamin-1 (EC 3.6.5.5)
1_MGNRG 6_ MEDLI 11_ PLVNR 16_ LQDAF 21_ SAIGQ 26_ NADLD 31_ LPQIA 36_ VVGGQ 41_ SAGKS 46_ SVLEN 51_ FVGRD 56_ FLPRG 61_ SGIVT 66_ RRPLV 71_ LQLVN 76_ ATTEY 81_ AEFLH 86_ CKGKK 91_ FTDFE 96_ EVRLE 101_ IEAET 106_ DRVTG 111_ TNKGI 116_ SPVPI 121_ NLRVY 126_ SPHVL 131_ NLTLV 136_ DLPGM 141_ TKVPV 146_ GDQPP 151_ DIEFQ 156_ IRDML 161_ MQFVT 166_ KENCL 171_ ILAVS 176_ PANSD 181_ LANSD 186_ ALKVA 191_ KEVDP 196_ QGQRT 201_ IGVIT 206_ KLDLM 211_ DEGTD 216_ ARDVL 221_ ENKLL 226_ PLRRG 231_ YIGVV 236_ NRSQK 241_ DIDGK 246_ KDITA 251_ ALAAE 256_ RKFFL 261_ SHPSY 266_ RHLAD 271_ RMGTP 276_ YLQKV 281_ LNQQL 286_ TNHIR 291_ DTLPG 296_ LRNKL 301_ QSQLL 306_ SIEKE 311_ VEEYK 316_ NFRPD 321_ DPARK 326_ TKALL 331_ QMVQQ 336_ FAVDF 341_ EKRIE 346_ GSGDQ 351_ IDTYE 356_ LSGGA 361_ RINRI 366_ FHERF 371_ PFELV 376_ KMEFD 381_ EKELR 386_ REISY 391_ AIKNI 396_ HGIRT 401_ GLFTP 406_ DMAFE 411_ TIVKK 416_ QVKKI 421_ REPCL 426_ KCVDM 431_ VISEL 436_ ISTVR 441_ QCTKK 446_ LQQYP 451_ RLREE 456_ MERIV 461_ TTHIR 466_ EREGR 471_ TKEQV 476_ MLLID 481_ IELAY 486_ MNTNH 491_ EDFIG 496_ FANAQ 501_ QRSNQ 506_ MNKKK 511_ TSGNQ 516_ DEILV 521_ IRKGW 526_ LTINN 531_ IGIMK 536_ GGSKE 541_ YWFVL 546_ TAENL 551_ SWYKD 556_ DEEKE 561_ KKYML 566_ SVDNL 571_ KLRDV 576_ EKGFM 581_ SSKHI 586_ FALFN 591_ TEQRN 596_ VYKDY 601_ RQLEL 606_ ACETQ 611_ EEVDS 616_ WKASF 621_ LRAGV 626_ YPERV 631_ GDKEK 636_ ASETE 641_ ENGSD 646_ SFMHS 651_ MDPQL 656_ ERQVE 661_ TIRNL 666_ VDSYM 671_ AIVNK 676_ TVRDL 681_ MPKTI 686_ MHLMI 691_ NNTKE 696_ FIFSE 701_ LLANL 706_ YSCGD 711_ QNTLM 716_ EESAE 721_ QAQRR 726_ DEMLR 731_ MYHAL 736_ KEALS 741_ IIGDI 746_ NTTTV 751_ STPMP 756_ PPVDD 761_ SWLQV 766_ QSVPA 771_ GRRSP 776_ TSSPT 781_ PQRRA 786_ PAVPP 791_ ARPGS 796_ RGPAP 801_ GPPPA 806_ GSALG 811_ GAPPV 816_ PSRPG 821_ ASPDP 826_ FGPPP 831_ QVPSR 836_ PNRAP 841_ PGVPS 846_ RSGQA 851_ SPSRP 856_ESPRP
1: Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276)