Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
1_MEQVE 6_ ILRKF 11_ IQRVQ 16_ AMKSP 21_ DHNGE 26_ DNFAR 31_ DFMRL 36_ RRLST 41_ KYRTE 46_ KIYPT 51_ ATGEK 56_ EENVK 61_ KNRYK 66_ DILPF 71_ DHSRV 76_ KLTLK 81_ TPSQD 86_ SDYIN 91_ ANFIK 96_ GVYGP 101_ KAYVA 106_ TQGPL 111_ ANTVI 116_ DFWRM 121_ IWEYN 126_ VVIIV 131_ MACRE 136_ FEMGR 141_ KKCER 146_ YWPLY 151_ GEDPI 156_ TFAPF 161_ KISCE 166_ DEQAR 171_ TDYFI 176_ RTLLL 181_ EFQNE 186_ SRRLY 191_ QFHYV 196_ NWPDH 201_ DVPSS 206_ FDSIL 211_ DMISL 216_ MRKYQ 221_ EHEDV 226_ PICIH 231_ CSAGC 236_ GRTGA 241_ ICAID 246_ YTWNL 251_ LKAGK 256_ IPEEF 261_ NVFNL 266_ IQEMR 271_ TQRHS 276_ AVQTK 281_ EQYEL 286_ VHRAI 291_ AQLFE 296_ KQLQL 301_ YEIHG 306_ AQKIA 311_ DGVNE 316_ INTEN 321_ MVSSI 326_ EPEKQ 331_ DSPPP 336_ KPPRT 341_ RSCLV 346_ EGDAK 351_ EEILQ 356_ PPEPH 361_ PVPPI 366_ LTPSP 371_ PSAFP 376_ TVTTV 381_ WQDND 386_ RYHPK 391_ PVLHM 396_ VSSEQ 401_ HSADL 406_ NRNYS 411_ KSTEL 416_ PGKNE 421_ STIEQ 426_ IDKKL 431_ ERNLS 436_ FEIKK 441_ VPLQE 446_ GPKSF 451_ DGNTL 456_ LNRGH 461_ AIKIK 466_ SASPC 471_ IADKI 476_ SKPQE 481_ LSSDL 486_ NVGDT 491_ SQNSC 496_ VDCSV 501_ TQSNK 506_ VSVTP 511_ PEESQ 516_ NSDTP 521_ PRPDR 526_ LPLDE 531_ KGHVT 536_ WSFHG 541_ PENAI 546_ PIPDL 551_ SEGNS 556_ SDINY 561_ QTRKT 566_ VSLTP 571_ SPTTQ 576_ VETPD 581_ LVDHD 586_ NTSPL 591_ FRTPL 596_ SFTNP 601_ LHSDD 606_ SDSDE 611_ RNSDG 616_ AVTQN 621_ KTNIS 626_ TASAT 631_ VSAAT 636_ STESI 641_ STRKV 646_ LPMSI 651_ ARHNI 656_ AGTTH 661_ SGAEK 666_ DVDVS 671_ EDSPP 676_ PLPER 681_ TPESF 686_ VLASE 691_ HNTPV 696_ RSEWS 701_ ELQSQ 706_ ERSEQ 711_ KKSEG 716_ LITSE 721_ NEKCD 726_ HPAGG 731_ IHYEM 736_ CIECP 741_ PTFSD 746_ KREQI 751_ SENPT 756_ EATDI 761_ GFGNR 766_ CGKPK 771_GPRDP
1: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172)