Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
1_MAAAY 6_ LDPNL 11_ NHTPN 16_ SSTKT 21_ HLGTG 26_ MERSP 31_ GAMER 36_ VLKVF 41_ HYFES 46_ NSEPT 51_ TWASI 56_ IRHGD 61_ ATDVR 66_ GIIQK 71_ IVDSH 76_ KVKHV 81_ ACYGF 86_ RLSHL 91_ RSEEV 96_ HWLHV 101_ DMGVS 106_ SVREK 111_ YELAH 116_ PPEEW 121_ KYELR 126_ IRYLP 131_ KGFLN 136_ QFTED 141_ KPTLN 146_ FFYQQ 151_ VKSDY 156_ MLEIA 161_ DQVDQ 166_ EIALK 171_ LGCLE 176_ IRRSY 181_ WEMRG 186_ NALEK 191_ KSNYE 196_ VLEKD 201_ VGLKR 206_ FFPKS 211_ LLDSV 216_ KAKTL 221_ RKLIQ 226_ QTFRQ 231_ FANLN 236_ REESI 241_ LKFFE 246_ ILSPV 251_ YRFDK 256_ ECFKC 261_ ALGSS 266_ WIISV 271_ ELAIG 276_ PEEGI 281_ SYLTD 286_ KGCNP 291_ THLAD 296_ FTQVQ 301_ TIQYS 306_ NSEDK 311_ DRKGM 316_ LQLKI 321_ AGAPE 326_ PLTVT 331_ APSLT 336_ IAENM 341_ ADLID 346_ GYCRL 351_ VNGTS 356_ QSFII 361_ RPQKE 366_ GERAL 371_ PSIPK 376_ LANSE 381_ KQGMR 386_ THAVS 391_ VSETD 396_ DYAEI 401_ IDEED 406_ TYTMP 411_ STRDY 416_ EIQRE 421_ RIELG 426_ RCIGE 431_ GQFGD 436_ VHQGI 441_ YMSPE 446_ NPALA 451_ VAIKT 456_ CKNCT 461_ SDSVR 466_ EKFLQ 471_ EALTM 476_ RQFDH 481_ PHIVK 486_ LIGVI 491_ TENPV 496_ WIIME 501_ LCTLG 506_ ELRSF 511_ LQVRK 516_ YSLDL 521_ ASLIL 526_ YAYQL 531_ STALA 536_ YLESK 541_ RFVHR 546_ DIAAR 551_ NVLVS 556_ SNDCV 561_ KLGDF 566_ GLSRY 571_ MEDST 576_ YYKAS 581_ KGKLP 586_ IKWMA 591_ PESIN 596_ FRRFT 601_ SASDV 606_ WMFGV 611_ CMWEI 616_ LMHGV 621_ KPFQG 626_ VKNND 631_ VIGRI 636_ ENGER 641_ LPMPP 646_ NCPPT 651_ LYSLM 656_ TKCWA 661_ YDPSR 666_ RPRFT 671_ ELKAQ 676_ LSTIL 681_ EEEKA 686_ QQEER 691_ MRMES 696_ RRQAT 701_ VSWDS 706_ GGSDE 711_ APPKP 716_ SRPGY 721_ PSPRS 726_ SEGFY 731_ PSPQH 736_ MVQTN 741_ HYQVS 746_ GYPGS 751_ HGITA 756_ MAGSI 761_ YPGQA 766_ SLLDQ 771_ TDSWN 776_ HRPQE 781_ IAMWQ 786_ PNVED 791_ STVLD 796_ LRGIG 801_ QVLPT 806_ HLMEE 811_ RLIRQ 816_ QQEME 821_ EDQRW 826_ LEKEE 831_ RFLKP 836_ DVRLS 841_ RGSID 846_ REDGS 851_ LQGPI 856_ GNQHI 861_ YQPVG 866_ KPDPA 871_ APPKK 876_ PPRPG 881_ APGHL 886_ GSLAS 891_ LSSPA 896_ DSYNE 901_ GVKLQ 906_ PQEIS 911_ PPPTA 916_ NLDRS 921_ NDKVY 926_ ENVTG 931_ LVKAV 936_ IEMSS 941_ KIQPA 946_ PPEEY 951_ VPMVK 956_ EVGLA 961_ LRTLL 966_ ATVDE 971_ TIPLL 976_ PASTH 981_ REIEM 986_ AQKLL 991_ NSDLG 996_ ELINK 1001_ MKLAQ 1006_ QYVMT 1011_ SLQQE 1016_ YKKQM 1021_ LTAAH 1026_ ALAVD 1031_ AKNLL 1036_ DVIDQ 1041_ ARLKM 1046_LGQTR
1: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription
2: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription