Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH)
1_MEPGS 6_ KSVSR 11_ SDWQP 16_ EPHQR 21_ PITPL 26_ EPGPE 31_ KTPIA 36_ QPESK 41_ TLQGS 46_ NTQQK 51_ PASNQ 56_ RPLTQ 61_ QETPA 66_ QHDAE 71_ SQKEP 76_ RAQQK 81_ SASQE 86_ EFLAP 91_ QKPAP 96_ QQSPY 101_ IQRVL 106_ LTQQE 111_ AASQQ 116_ GPGLG 121_ KESIT 126_ QQEPA 131_ LRQRH 136_ VAQPG 141_ PGPGE 146_ PPPAQ 151_ QEAES 156_ TPAAQ 161_ AKPGA 166_ KREPS 171_ APTES 176_ TSQET 181_ PEQSD 186_ KQTTP 191_ VQGAK 196_ SKQGS 201_ LTELG 206_ FLTKL 211_ QELSI 216_ QRSAL 221_ EWKAL 226_ SEWVT 231_ DSESE 236_ SDVGS 241_ SSDTD 246_ SPATM 251_ GGMVA 256_ QGVKL 261_ GFKGK 266_ SGYKV 271_ MSGYS 276_ GTSPH 281_ EKTSA 286_ RNHRH 291_ YQDTA 296_ SRLIH 301_ NMDLR 306_ TMTQS 311_ LVTLA 316_ EDNIA 321_ FFSSQ 326_ GPGET 331_ AQRLS 336_ GVFAG 341_ VREQA 346_ LGLEP 351_ ALGRL 356_ LGVAH 361_ LFDLD 366_ PETPA 371_ NGYRS 376_ LVHTA 381_ RCCLA 386_ HLLHK 391_ SRYVA 396_ SNRRS 401_ IFFRT 406_ SHNLA 411_ ELEAY 416_ LAALT 421_ QLRAL 426_ VYYAQ 431_ RLLVT 436_ NRPGV 441_ LFFEG 446_ DEGLT 451_ ADFLR 456_ EYVTL 461_ HKGCF 466_ YGRCL 471_ GFQFT 476_ PAIRP 481_ FLQTI 486_ SIGLV 491_ SFGEH 496_ YKRNE 501_ TGLSV 506_ AASSL 511_ FTSGR 516_ FAIDP 521_ ELRGA 526_ EFERI 531_ TQNLD 536_ VHFWK 541_ AFWNI 546_ TEMEV 551_ LSSLA 556_ NMASA 561_ TVRVS 566_ RLLSL 571_ PPEAF 576_ EMPLT 581_ ADPTL 586_ TVTIS 591_ PPLAH 596_ TGPGP 601_ VLVRL 606_ ISYDL 611_ REGQD 616_ SEELS 621_ SLIKS 626_ NGQRS 631_ LELWP 636_ RPQQA 641_ PRSRS 646_ LIVHF 651_ HGGGF 656_ VAQTS 661_ RSHEP 666_ YLKSW 671_ AQELG 676_ APIIS 681_ IDYSL 686_ APEAP 691_ FPRAL 696_ EECFF 701_ AYCWA 706_ IKHCA 711_ LLGST 716_ GERIC 721_ LAGDS 726_ AGGNL 731_ CFTVA 736_ LRAAA 741_ YGVRV 746_ PDGIM 751_ AAYPA 756_ TMLQP 761_ AASPS 766_ RLLSL 771_ MDPLL 776_ PLSVL 781_ SKCVS 786_ AYAGA 791_ KTEDH 796_ SNSDQ 801_ KALGM 806_ MGLVR 811_ RDTAL 816_ LLRDF 821_ RLGAS 826_ SWLNS 831_ FLELS 836_ GRKSQ 841_ KMSEP 846_ IAEPM 851_ RRSVS 856_ EAALA 861_ QPQGP 866_ LGTDS 871_ LKNLT 876_ LRDLS 881_ LRGNS 886_ ETSSD 891_ TPEMS 896_ LSAET 901_ LSPST 906_ PSDVN 911_ FLLPP 916_ EDAGE 921_ EAEAK 926_ NELSP 931_ MDRGL 936_ GVRAA 941_ FPEGF 946_ HPRRS 951_ SQGAT 956_ QMPLY 961_ SSPIV 966_ KNPFM 971_ SPLLA 976_ PDSML 981_ KSLPP 986_ VHIVA 991_ CALDP 996_ MLDDS 1001_ VMLAR 1006_ RLRNL 1011_ GQPVT 1016_ LRVVE 1021_ DLPHG 1026_ FLTLA 1031_ ALCRE 1036_ TRQAA 1041_ ELCVE 1046_ RIRLV 1051_ LTPPA 1056_ GAGPS 1061_ GETGA 1066_ AGVDG 1071_GCGGR
1: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:8812477). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity)