Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
1_MPSRT 6_ GPKME 11_ GSGGR 16_ VRLKA 21_ HYGGD 26_ IFITS 31_ VDAAT 36_ TFEEL 41_ CEEVR 46_ DMCRL 51_ HQQHP 56_ LTLKW 61_ VDSEG 66_ DPCTV 71_ SSQME 76_ LEEAF 81_ RLARQ 86_ CRDEG 91_ LIIHV 96_ FPSTP 101_ EQPGL 106_ PCPGE 111_ DKSIY 116_ RRGAR 121_ RWRKL 126_ YRANG 131_ HLFQA 136_ KRFNR 141_ RAYCG 146_ QCSER 151_ IWGLA 156_ RQGYR 161_ CINCK 166_ LLVHK 171_ RCHGL 176_ VPLTC 181_ RKHMD 186_ SVMPS 191_ QEPPV 196_ DDKNE 201_ DADLP 206_ SEETD 211_ GIAYI 216_ SSSRK 221_ HDSIK 226_ DDSED 231_ LKPVI 236_ DGMDG 241_ IKISQ 246_ GLGLQ 251_ DFDLI 256_ RVIGR 261_ GSYAK 266_ VLLVR 271_ LKKND 276_ QIYAM 281_ KVVKK 286_ ELVHD 291_ DEDID 296_ WVQTE 301_ KHVFE 306_ QASSN 311_ PFLVG 316_ LHSCF 321_ QTTSR 326_ LFLVI 331_ EYVNG 336_ GDLMF 341_ HMQRQ 346_ RKLPE 351_ EHARF 356_ YAAEI 361_ CIALN 366_ FLHER 371_ GIIYR 376_ DLKLD 381_ NVLLD 386_ ADGHI 391_ KLTDY 396_ GMCKE 401_ GLGPG 406_ DTTST 411_ FCGTP 416_ NYIAP 421_ EILRG 426_ EEYGF 431_ SVDWW 436_ ALGVL 441_ MFEMM 446_ AGRSP 451_ FDIIT 456_ DNPDM 461_ NTEDY 466_ LFQVI 471_ LEKPI 476_ RIPRF 481_ LSVKA 486_ SHVLK 491_ GFLNK 496_ DPKER 501_ LGCRP 506_ QTGFS 511_ DIKSH 516_ AFFRS 521_ IDWDL 526_ LEKKQ 531_ ALPPF 536_ QPQIT 541_ DDYGL 546_ DNFDT 551_ QFTSE 556_ PVQLT 561_ PDDED 566_ AIKRI 571_ DQSEF 576_ EGFEY 581_ INPLL 586_LSTEE
1: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231)
2: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance