Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)
1_MDLTK 6_ MGMIQ 11_ LQNPS 16_ HPTGL 21_ LCKAN 26_ QMRLA 31_ GTLCD 36_ VVIMV 41_ DSQEF 46_ HAHRT 51_ VLACT 56_ SKMFE 61_ ILFHR 66_ NSQHY 71_ TLDFL 76_ SPKTF 81_ QQILE 86_ YAYTA 91_ TLQAK 96_ AEDLD 101_ DLLYA 106_ AEILE 111_ IEYLE 116_ EQCLK 121_ MLETI 126_ QASDD 131_ NDTEA 136_ TMADG 141_ GAEEE 146_ EDRKA 151_ RYLKN 156_ IFISK 161_ HSSEE 166_ SGYAS 171_ VAGQS 176_ LPGPM 181_ VDQSP 186_ SVSTS 191_ FGLSA 196_ MSPTK 201_ AAVDS 206_ LMTIG 211_ QSLLQ 216_ GTLQP 221_ PAGPE 226_ EPTLA 231_ GGGRH 236_ PGVAE 241_ VKTEM 246_ MQVDE 251_ VPSQD 256_ SPGAA 261_ ESSIS 266_ GGMGD 271_ KVEER 276_ GKEGP 281_ GTPTR 286_ SSVIT 291_ SAREL 296_ HYGRE 301_ ESAEQ 306_ VPPPA 311_ EAGQA 316_ PTGRP 321_ EHPAP 326_ PPEKH 331_ LGIYS 336_ VLPNH 341_ KADAV 346_ LSMPS 351_ SVTSG 356_ LHVQP 361_ ALAVS 366_ MDFST 371_ YGGLL 376_ PQGFI 381_ QRELF 386_ SKLGE 391_ LAVGM 396_ KSESR 401_ TIGEQ 406_ CSVCG 411_ VELPD 416_ NEAVE 421_ QHRKL 426_ HSGMK 431_ TYGCE 436_ LCGKR 441_ FLDSL 446_ RLRMH 451_ LLAHS 456_ AGAKA 461_ FVCDQ 466_ CGAQF 471_ SKEDA 476_ LETHR 481_ QTHTG 486_ TDMAV 491_ FCLLC 496_ GKRFQ 501_ AQSAL 506_ QQHME 511_ VHAGV 516_ RSYIC 521_ SECNR 526_ TFPSH 531_ TALKR 536_ HLRSH 541_ TGDHP 546_ YECEF 551_ CGSCF 556_ RDEST 561_ LKSHK 566_ RIHTG 571_ EKPYE 576_ CNGCG 581_ KKFSL 586_ KHQLE 591_ THYRV 596_ HTGEK 601_ PFECK 606_ LCHQR 611_ SRDYS 616_ AMIKH 621_ LRTHN 626_ GASPY 631_ QCTIC 636_ TEYCP 641_ SLSSM 646_ QKHMK 651_ GHKPE 656_ EIPPD 661_ WRIEK 666_TYLYL
1: Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312)