Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
1_MSTMR 6_ LLTLA 11_ LLFSC 16_ SVARA 21_ ACDPK 26_ IVNIG 31_ AVLST 36_ RKHEQ 41_ MFREA 46_ VNQAN 51_ KRHGS 56_ WKIQL 61_ NATSV 66_ THKPN 71_ AIQMA 76_ LSVCE 81_ DLISS 86_ QVYAI 91_ LVSHP 96_ PTPND 101_ HFTPT 106_ PVSYT 111_ AGFYR 116_ IPVLG 121_ LTTRM 126_ SIYSD 131_ KSIHL 136_ SFLRT 141_ VPPYS 146_ HQSSV 151_ WFEMM 156_ RVYSW 161_ NHIIL 166_ LVSDD 171_ HEGRA 176_ AQKRL 181_ ETLLE 186_ ERESK 191_ AEKVL 196_ QFDPG 201_ TKNVT 206_ ALLME 211_ AKELE 216_ ARVII 221_ LSASE 226_ DDAAT 231_ VYRAA 236_ AMLNM 241_ TGSGY 246_ VWLVG 251_ EREIS 256_ GNALR 261_ YAPDG 266_ ILGLQ 271_ LINGK 276_ NESAH 281_ ISDAV 286_ GVVAQ 291_ AVHEL 296_ LEKEN 301_ ITDPP 306_ RGCVG 311_ NTNIW 316_ KTGPL 321_ FKRVL 326_ MSSKY 331_ ADGVT 336_ GRVEF 341_ NEDGD 346_ RKFAN 351_ YSIMN 356_ LQNRK 361_ LVQVG 366_ IYNGT 371_ HVIPN 376_ DRKII 381_ WPGGE 386_ TEKPR 391_ GYQMS 396_ TRLKI 401_ VTIHQ 406_ EPFVY 411_ VKPTL 416_ SDGTC 421_ KEEFT 426_ VNGDP 431_ VKKVI 436_ CTGPN 441_ DTSPG 446_ SPRHT 451_ VPQCC 456_ YGFCI 461_ DLLIK 466_ LARTM 471_ NFTYE 476_ VHLVA 481_ DGKFG 486_ TQERV 491_ NNSNK 496_ KEWNG 501_ MMGEL 506_ LSGQA 511_ DMIVA 516_ PLTIN 521_ NERAQ 526_ YIEFS 531_ KPFKY 536_ QGLTI 541_ LVKKE 546_ IPRST 551_ LDSFM 556_ QPFQS 561_ TLWLL 566_ VGLSV 571_ HVVAV 576_ MLYLL 581_ DRFSP 586_ FGRFK 591_ VNSEE 596_ EEEDA 601_ LTLSS 606_ AMWFS 611_ WGVLL 616_ NSGIG 621_ EGAPR 626_ SFSAR 631_ ILGMV 636_ WAGFA 641_ MIIVA 646_ SYTAN 651_ LAAFL 656_ VLDRP 661_ EERIT 666_ GINDP 671_ RLRNP 676_ SDKFI 681_ YATVK 686_ QSSVD 691_ IYFRR 696_ QVELS 701_ TMYRH 706_ MEKHN 711_ YESAA 716_ EAIQA 721_ VRDNK 726_ LHAFI 731_ WDSAV 736_ LEFEA 741_ SQKCD 746_ LVTTG 751_ ELFFR 756_ SGFGI 761_ GMRKD 766_ SPWKQ 771_ NVSLS 776_ ILKSH 781_ ENGFM 786_ EDLDK 791_ TWVRY 796_ QECDS 801_ RSNAP 806_ ATLTF 811_ ENMAG 816_ VFMLV 821_ AGGIV 826_ AGIFL 831_ IFIEI 836_ AYKRH 841_ KDARR 846_ KQMQL 851_ AFAAV 856_ NVWRK 861_ NLQDR 866_ KSGRA 871_ EPDPK 876_ KKATF 881_ RAITS 886_ TLASS 891_ FKRRR 896_ SSKDT 901_ STGGG 906_ RGALQ 911_ NQKDT 916_ VLPRR 921_ AIERE 926_ EGQLQ 931_LCSRH
1: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed:26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:27164704, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:38538865, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761, PubMed:36309015, PubMed:38598639)