2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L)
1_MESRD 6_ HNNPQ 11_ EGPTS 16_ SSGRR 21_ AAVED 26_ NHLLI 31_ KAVQN 36_ EDVDL 41_ VQQLL 46_ EGGAN 51_ VNFQE 56_ EEGGW 61_ TPLHN 66_ AVQMS 71_ REDIV 76_ ELLLR 81_ HGADP 86_ VLRKK 91_ NGATP 96_ FILAA 101_ IAGSV 106_ KLLKL 111_ FLSKG 116_ ADVNE 121_ CDFYG 126_ FTAFM 131_ EAAVY 136_ GKVKA 141_ LKFLY 146_ KRGAN 151_ VNLRR 156_ KTKED 161_ QERLR 166_ KGGAT 171_ ALMDA 176_ AEKGH 181_ VEVLK 186_ ILLDE 191_ MGADV 196_ NACDN 201_ MGRNA 206_ LIHAL 211_ LSSDD 216_ SDVEA 221_ ITHLL 226_ LDHGA 231_ DVNVR 236_ GERGK 241_ TPLIL 246_ AVEKK 251_ HLGLV 256_ QRLLE 261_ QEHIE 266_ INDTD 271_ SDGKT 276_ ALLLA 281_ VELKL 286_ KKIAE 291_ LLCKR 296_ GASTD 301_ CGDLV 306_ MTARR 311_ NYDHS 316_ LVKVL 321_ LSHGA 326_ KEDFH 331_ PPAED 336_ WKPQS 341_ SHWGA 346_ ALKDL 351_ HRIYR 356_ PMIGK 361_ LKFFI 366_ DEKYK 371_ IADTS 376_ EGGIY 381_ LGFYE 386_ KQEVA 391_ VKTFC 396_ EGSPR 401_ AQREV 406_ SCLQS 411_ SRENS 416_ HLVTF 421_ YGSES 426_ HRGHL 431_ FVCVT 436_ LCEQT 441_ LEACL 446_ DVHRG 451_ EDVEN 456_ EEDEF 461_ ARNVL 466_ SSIFK 471_ AVQEL 476_ HLSCG 481_ YTHQD 486_ LQPQN 491_ ILIDS 496_ KKAAH 501_ LADFD 506_ KSIKW 511_ AGDPQ 516_ EVKRD 521_ LEDLG 526_ RLVLY 531_ VVKKG 536_ SISFE 541_ DLKAQ 546_ SNEEV 551_ VQLSP 556_ DEETK 561_ DLIHR 566_ LFHPG 571_ EHVRD 576_ CLSDL 581_ LGHPF 586_ FWTWE 591_ SRYRT 596_ LRNVG 601_ NESDI 606_ KTRKS 611_ ESEIL 616_ RLLQP 621_ GPSEH 626_ SKSFD 631_ KWTTK 636_ INECV 641_ MKKMN 646_ KFYEK 651_ RGNFY 656_ QNTVG 661_ DLLKF 666_ IRNLG 671_ EHIDE 676_ EKHKK 681_ MKLKI 686_ GDPSL 691_ YFQKT 696_ FPDLV 701_ IYVYT 706_ KLQNT 711_ EYRKH 716_ FPQTH 721_ SPNKP 726_ QCDGA 731_ GGASG 736_LASPG
1: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length