Neuronal acetylcholine receptor subunit beta-3
1_MLPDF 6_ MLVLI 11_ VLGIP 16_ SSATT 21_ GFNSI 26_ AENED 31_ ALLRH 36_ LFQGY 41_ QKWVR 46_ PVLHS 51_ NDTIK 56_ VYFGL 61_ KISQL 66_ VDVDE 71_ KNQLM 76_ TTNVW 81_ LKQEW 86_ TDHKL 91_ RWNPD 96_ DYGGI 101_ HSIKV 106_ PSESL 111_ WLPDI 116_ VLFEN 121_ ADGRF 126_ EGSLM 131_ TKVIV 136_ KSNGT 141_ VVWTP 146_ PASYK 151_ SSCTM 156_ DVTFF 161_ PFDRQ 166_ NCSMK 171_ FGSWT 176_ YDGTM 181_ VDLIL 186_ INENV 191_ DRKDF 196_ FDNGE 201_ WEILN 206_ AKGMK 211_ GNRRD 216_ GVYSY 221_ PFITY 226_ SFVLR 231_ RLPLF 236_ YTLFL 241_ IIPCL 246_ GLSFL 251_ TVLVF 256_ YLPSD 261_ EGEKL 266_ SLSTS 271_ VLVSL 276_ TVFLL 281_ VIEEI 286_ IPSSS 291_ KVIPL 296_ IGEYL 301_ LFIMI 306_ FVTLS 311_ IIVTV 316_ FVINV 321_ HHRSS 326_ STYHP 331_ MAPWV 336_ KRLFL 341_ QKLPK 346_ LLCMK 351_ DHVDR 356_ YSSPE 361_ KEESQ 366_ PVVKG 371_ KVLEK 376_ KKQKQ 381_ LSDGE 386_ KVLVA 391_ FLEKA 396_ ADSIR 401_ YISRH 406_ VKKEH 411_ FISQV 416_ VQDWK 421_ FVAQV 426_ LDRIF 431_ LWLFL 436_ IVSVT 441_ GSVLI 446_ FTPAL 451_KMWLH
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11118490, PubMed:16835356, PubMed:35889515). Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit (PubMed:11118490, PubMed:16835356). Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4 (PubMed:11118490, PubMed:16835356). Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4 (PubMed:11118490, PubMed:16835356). Seems to play a role in nicotine addiction (PubMed:11118490, PubMed:16835356)