Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)
1_MGLEA 6_ ARELE 11_ CAALG 16_ TLLRD 21_ PREAE 26_ RTLLL 31_ DCRPF 36_ LAFCR 41_ RHVRA 46_ ARPVP 51_ WNALL 56_ RRRAR 61_ GPPAA 66_ VLACL 71_ LPDRA 76_ LRTRL 81_ VRGEL 86_ ARAVV 91_ LDEGS 96_ ASVAE 101_ LRPDS 106_ PAHVL 111_ LAALL 116_ HETRA 121_ GPTAV 126_ YFLRG 131_ GFDGF 136_ QGCCP 141_ DLCSE 146_ APAPA 151_ LPPTG 156_ DKTSR 161_ SDSRA 166_ PVYDQ 171_ GGPVE 176_ ILPYL 181_ FLGSC 186_ SHSSD 191_ LQGLQ 196_ ACGIT 201_ AVLNV 206_ SASCP 211_ NHFEG 216_ LFRYK 221_ SIPVE 226_ DNQMV 231_ EISAW 236_ FQEAI 241_ GFIDW 246_ VKNSG 251_ GRVLV 256_ HCQAG 261_ ISRSA 266_ TICLA 271_ YLMQS 276_ RRVRL 281_ DEAFD 286_ FVKQR 291_ RGVIS 296_ PNFSF 301_ MGQLL 306_QFETQ
1: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity)