Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)
1_MSRAR 6_ SHLRA 11_ ALFLA 16_ AASAR 21_ GITTQ 26_ VAARR 31_ GLSAW 36_ PVPQE 41_ PSMEY 46_ QDAVR 51_ MLNTL 56_ QTNAG 61_ YLEQV 66_ KRQRG 71_ DPQTQ 76_ LEAME 81_ LYLAR 86_ SGLQV 91_ EDLDR 96_ LNIIH 101_ VTGTK 106_ GKGST 111_ CAFTE 116_ CILRS 121_ YGLKT 126_ GFFSS 131_ PHLVQ 136_ VRERI 141_ RINGQ 146_ PISPE 151_ LFTKY 156_ FWRLY 161_ HRLEE 166_ TKDGS 171_ CVSMP 176_ PYFRF 181_ LTLMA 186_ FHVFL 191_ QEKVD 196_ LAVVE 201_ VGIGG 206_ AYDCT 211_ NIIRK 216_ PVVCG 221_ VSSLG 226_ IDHTS 231_ LLGDT 236_ VEKIA 241_ WQKGG 246_ IFKQG 251_ VPAFT 256_ VLQPE 261_ GPLAV 266_ LRDRA 271_ QQISC 276_ PLYLC 281_ PMLEA 286_ LEEGG 291_ PPLTL 296_ GLEGE 301_ HQRSN 306_ AALAL 311_ QLAHC 316_ WLQRQ 321_ DRHGA 326_ GEPKA 331_ SRPGL 336_ LWQLP 341_ LAPVF 346_ QPTSH 351_ MRLGL 356_ RNTEW 361_ PGRTQ 366_ VLRRG 371_ PLTWY 376_ LDGAH 381_ TASSA 386_ QACVR 391_ WFRQA 396_ LQGRE 401_ RPSGG 406_ PEVRV 411_ LLFNA 416_ TGDRD 421_ PAALL 426_ KLLQP 431_ CQFDY 436_ AVFCP 441_ NLTEV 446_ SSTGN 451_ ADQQN 456_ FTVTL 461_ DQVLL 466_ RCLEH 471_ QQHWN 476_ HLDEE 481_ QASPD 486_ LWSAP 491_ SPEPG 496_ GSASL 501_ LLAPH 506_ PPHTC 511_ SASSL 516_ VFSCI 521_ SHALQ 526_ WISQG 531_ RDPIF 536_ QPPSP 541_ PKGLL 546_ THPVA 551_ HSGAS 556_ ILREA 561_ AAIHV 566_ LVTGS 571_ LHLVG 576_ GVLKL 581_LEPAL
1: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates