Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
1_MALSE 6_ LALVR 11_ WLQES 16_ RRSRK 21_ LILFI 26_ VFLAL 31_ LLDNM 36_ LLTVV 41_ VPIIP 46_ SYLYS 51_ IKHEK 56_ NATEI 61_ QTARP 66_ VHTAS 71_ ISDSF 76_ QSIFS 81_ YYDNS 86_ TMVTG 91_ NATRD 96_ LTLHQ 101_ TATQH 106_ MVTNA 111_ SAVPS 116_ DCPSE 121_ DKDLL 126_ NENVQ 131_ VGLLF 136_ ASKAT 141_ VQLIT 146_ NPFIG 151_ LLTNR 156_ IGYPI 161_ PIFAG 166_ FCIMF 171_ VSTIM 176_ FAFSS 181_ SYAFL 186_ LIARS 191_ LQGIG 196_ SSCSS 201_ VAGMG 206_ MLASV 211_ YTDDE 216_ ERGNV 221_ MGIAL 226_ GGLAM 231_ GVLVG 236_ PPFGS 241_ VLYEF 246_ VGKTA 251_ PFLVL 256_ AALVL 261_ LDGAI 266_ QLFVL 271_ QPSRV 276_ QPESQ 281_ KGTPL 286_ TTLLK 291_ DPYIL 296_ IAAGS 301_ ICFAN 306_ MGIAM 311_ LEPAL 316_ PIWMM 321_ ETMCS 326_ RKWQL 331_ GVAFL 336_ PASIS 341_ YLIGT 346_ NIFGI 351_ LAHKM 356_ GRWLC 361_ ALLGM 366_ IIVGV 371_ SILCI 376_ PFAKN 381_ IYGLI 386_ APNFG 391_ VGFAI 396_ GMVDS 401_ SMMPI 406_ MGYLV 411_ DLRHV 416_ SVYGS 421_ VYAIA 426_ DVAFC 431_ MGYAI 436_ GPSAG 441_ GAIAK 446_ AIGFP 451_ WLMTI 456_ IGIID 461_ ILFAP 466_ LCFFL 471_ RSPPA 476_ KEEKM 481_ AILMD 486_ HNCPI 491_ KTKMY 496_ TQNNI 501_ QSYPI 506_GEDEE
1: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:23363473, PubMed:37914936, PubMed:38081299, PubMed:38517752, PubMed:8643547). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238)