MBT domain-containing protein 1
1_MFDGY 6_ DSCSE 11_ DTSSS 16_ SSSEE 21_ SEEEV 26_ APLPS 31_ NLPII 36_ KNNGQ 41_ VYTYP 46_ DGKSG 51_ MATCE 56_ MCGMV 61_ GVRDA 66_ FYSKT 71_ KRFCS 76_ VSCSR 81_ SYSSN 86_ SKKAS 91_ ILARL 96_ QGKPP 101_ TKKAK 106_ VLQKQ 111_ PLVAK 116_ LAAYA 121_ QYQAT 126_ LQNQA 131_ KTKAA 136_ VSMEG 141_ FSWGN 146_ YINSN 151_ SFIAA 156_ PVTCF 161_ KHAPM 166_ GTCWG 171_ DISEN 176_ VRVEV 181_ PNTDC 186_ SLPTK 191_ VFWIA 196_ GIVKL 201_ AGYNA 206_ LLRYE 211_ GFEND 216_ SGLDF 221_ WCNIC 226_ GSDIH 231_ PVGWC 236_ AASGK 241_ PLVPP 246_ RTIQH 251_ KYTNW 256_ KAFLV 261_ KRLTG 266_ AKTLP 271_ PDFSQ 276_ KVSES 281_ MQYPF 286_ KPCMR 291_ VEVVD 296_ KRHLC 301_ RTRVA 306_ VVESV 311_ IGGRL 316_ RLVYE 321_ ESEDR 326_ TDDFW 331_ CHMHS 336_ PLIHH 341_ IGWSR 346_ SIGHR 351_ FKRSD 356_ ITKKQ 361_ DGHFD 366_ TPPHL 371_ FAKVK 376_ EVDQS 381_ GEWFK 386_ EGMKL 391_ EAIDP 396_ LNLST 401_ ICVAT 406_ IRKVL 411_ ADGFL 416_ MIGID 421_ GSEAA 426_ DGSDW 431_ FCYHA 436_ TSPSI 441_ FPVGF 446_ CEINM 451_ IELTP 456_ PRGYT 461_ KLPFK 466_ WFDYL 471_ RETGS 476_ IAAPV 481_ KLFNK 486_ DVPNH 491_ GFRVG 496_ MKLEA 501_ VDLME 506_ PRLIC 511_ VATVT 516_ RIIHR 521_ LLRIH 526_ FDGWE 531_ EEYDQ 536_ WVDCE 541_ SPDLY 546_ PVGWC 551_ QLTGY 556_ QLQPP 561_ ASQSS 566_ RENQS 571_ ASSKQ 576_ KKKAK 581_ SQQYK 586_ GHKKM 591_ TTLQL 596_ KEELL 601_ DGEDY 606_ NFLQG 611_ ASDQE 616_ SNGSA 621_NFYIK
1: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538)