Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
1_MTSRR 6_ WFHPN 11_ ITGVE 16_ AENLL 21_ LTRGV 26_ DGSFL 31_ ARPSK 36_ SNPGD 41_ FTLSV 46_ RRNGA 51_ VTHIK 56_ IQNTG 61_ DYYDL 66_ YGGEK 71_ FATLA 76_ ELVQY 81_ YMEHH 86_ GQLKE 91_ KNGDV 96_ IELKY 101_ PLNCA 106_ DPTSE 111_ RWFHG 116_ HLSGK 121_ EAEKL 126_ LTEKG 131_ KHGSF 136_ LVRES 141_ QSHPG 146_ DFVLS 151_ VRTGD 156_ DKGES 161_ NDGKS 166_ KVTHV 171_ MIRCQ 176_ ELKYD 181_ VGGGE 186_ RFDSL 191_ TDLVE 196_ HYKKN 201_ PMVET 206_ LGTVL 211_ QLKQP 216_ LNTTR 221_ INAAE 226_ IESRV 231_ RELSK 236_ LAETT 241_ DKVKQ 246_ GFWEE 251_ FETLQ 256_ QQECK 261_ LLYSR 266_ KEGQR 271_ QENKN 276_ KNRYK 281_ NILPF 286_ DHTRV 291_ VLHDG 296_ DPNEP 301_ VSDYI 306_ NANII 311_ MPEFE 316_ TKCNN 321_ SKPKK 326_ SYIAT 331_ QGCLQ 336_ NTVND 341_ FWRMV 346_ FQENS 351_ RVIVM 356_ TTKEV 361_ ERGKS 366_ KCVKY 371_ WPDEY 376_ ALKEY 381_ GVMRV 386_ RNVKE 391_ SAAHD 396_ YTLRE 401_ LKLSK 406_ VGQGN 411_ TERTV 416_ WQYHF 421_ RTWPD 426_ HGVPS 431_ DPGGV 436_ LDFLE 441_ EVHHK 446_ QESIM 451_ DAGPV 456_ VVHCS 461_ AGIGR 466_ TGTFI 471_ VIDIL 476_ IDIIR 481_ EKGVD 486_ CDIDV 491_ PKTIQ 496_ MVRSQ 501_ RSGMV 506_ QTEAQ 511_ YRFIY 516_ MAVQH 521_ YIETL 526_ QRRIE 531_ EEQKS 536_ KRKGH 541_ EYTNI 546_ KYSLA 551_ DQTSG 556_ DQSPL 561_ PPCTP 566_ TPPCA 571_ EMRED 576_ SARVY 581_ ENVGL 586_MQQQK
1: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884)