Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]
1_MLPPM 6_ ALPSV 11_ SWMLL 16_ SCLML 21_ LSQVQ 26_ GEEPQ 31_ RELPS 36_ ARIRC 41_ PKGSK 46_ AYGSH 51_ CYALF 56_ LSPKS 61_ WTDAD 66_ LACQK 71_ RPSGN 76_ LVSVL 81_ SGAEG 86_ SFVSS 91_ LVKSI 96_ GNSYS 101_ YVWIG 106_ LHDPT 111_ QGTEP 116_ NGEGW 121_ EWSSS 126_ DVMNY 131_ FAWER 136_ NPSTI 141_ SSPGH 146_ CASLS 151_ RSTAF 156_ LRWKD 161_ YNCNV 166_RLPYV
1: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734)
2: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:19158046, PubMed:22727489, PubMed:27830702, PubMed:34099862). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:19158046)
3: Has bacteriostatic activity