Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)
1_MKETP 6_ LSNCE 11_ RRFLL 16_ RAIEE 21_ KKRLD 26_ GRQTY 31_ DYRNI 36_ RISFG 41_ TDYGC 46_ CIVEL 51_ GKTRV 56_ LGQVS 61_ CELVS 66_ PKLNR 71_ ATEGI 76_ LFFNL 81_ ELSQM 86_ AAPAF 91_ EPGRQ 96_ SDLLV 101_ KLNRL 106_ MERCL 111_ RNSKC 116_ IDTES 121_ LCVVA 126_ GEKVW 131_ QIRVD 136_ LHLLN 141_ HDGNI 146_ IDAAS 151_ IAAIV 156_ ALCHF 161_ RRPDV 166_ SVQGD 171_ EVTLY 176_ TPEER 181_ DPVPL 186_ SIHHM 191_ PICVS 196_ FAFFQ 201_ QGTYL 206_ LVDPN 211_ EREER 216_ VMDGL 221_ LVIAM 226_ NKHRE 231_ ICTIQ 236_ SSGGI 241_ MLLKD 246_ QVLRC 251_ SKIAG 256_ VKVAE 261_ ITELI 266_ LKALE 271_ NDQKV 276_ RKEGG 281_ KFGFA 286_ ESIAN 291_ QRITA 296_ FKMEK 301_ APIDT 306_ SDVEE 311_ KAEEI 316_ IAEAE 321_ PPSEV 326_ VSTPV 331_ LWTPG 336_ TAQIG 341_ EGVEN 346_ SWGDL 351_ EDSEK 356_ EDDEG 361_ GGDQA 366_ IILDG 371_ IKMDT 376_ GVEVS 381_ DIGSQ 386_ DAPII 391_ LSDSE 396_ EEEMI 401_ ILEPD 406_ KNPKK 411_ IRTQT 416_ TSAKQ 421_ EKAPS 426_ KKPVK 431_RRKKK
1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs