Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-)
1_MDRAS 6_ ELLFY 11_ VNGRK 16_ VIEKN 21_ VDPET 26_ MLLPY 31_ LRKKL 36_ RLTGT 41_ KYGCG 46_ GGGCG 51_ ACTVM 56_ ISRYN 61_ PITKR 66_ IRHHP 71_ ANACL 76_ IPICS 81_ LYGAA 86_ VTTVE 91_ GIGST 96_ HTRIH 101_ PVQER 106_ IAKCH 111_ GTQCG 116_ FCTPG 121_ MVMSI 126_ YTLLR 131_ NHPEP 136_ TLDQL 141_ TDALG 146_ GNLCR 151_ CTGYR 156_ PIIDA 161_ CKTFC 166_ KTSGC 171_ CQSKE 176_ NGVCC 181_ LDQGI 186_ NGLPE 191_ FEEGS 196_ KTSPK 201_ LFAEE 206_ EFLPL 211_ DPTQE 216_ LIFPP 221_ ELMIM 226_ AEKQS 231_ QRTRV 236_ FGSER 241_ MMWFS 246_ PVTLK 251_ ELLEF 256_ KFKYP 261_ QAPVI 266_ MGNTS 271_ VGPEV 276_ KFKGV 281_ FHPVI 286_ ISPDR 291_ IEELS 296_ VVNHA 301_ YNGLT 306_ LGAGL 311_ SLAQV 316_ KDILA 321_ DVVQK 326_ LPEEK 331_ TQMYH 336_ ALLKH 341_ LGTLA 346_ GSQIR 351_ NMASL 356_ GGHII 361_ SRHPD 366_ SDLNP 371_ ILAVG 376_ NCTLN 381_ LLSKE 386_ GKRQI 391_ PLNEQ 396_ FLSKC 401_ PNADL 406_ KPQEI 411_ LVSVN 416_ IPYSR 421_ KWEFV 426_ SAFRQ 431_ AQRQE 436_ NALAI 441_ VNSGM 446_ RVFFG 451_ EGDGI 456_ IRELC 461_ ISYGG 466_ VGPAT 471_ ICAKN 476_ SCQKL 481_ IGRHW 486_ NEQML 491_ DIACR 496_ LILNE 501_ VSLLG 506_ SAPGG 511_ KVEFK 516_ RTLII 521_ SFLFK 526_ FYLEV 531_ SQILK 536_ KMDPV 541_ HYPSL 546_ ADKYE 551_ SALED 556_ LHSKH 561_ HCSTL 566_ KYQNI 571_ GPKQH 576_ PEDPI 581_ GHPIM 586_ HLSGV 591_ KHATG 596_ EAIYC 601_ DDMPL 606_ VDQEL 611_ FLTFV 616_ TSSRA 621_ HAKIV 626_ SIDLS 631_ EALSM 636_ PGVVD 641_ IMTAE 646_ HLSDV 651_ NSFCF 656_ FTEAE 661_ KFLAT 666_ DKVFC 671_ VGQLV 676_ CAVLA 681_ DSEVQ 686_ AKRAA 691_ KRVKI 696_ VYQDL 701_ EPLIL 706_ TIEES 711_ IQHNS 716_ SFKPE 721_ RKLEY 726_ GNVDE 731_ AFKVV 736_ DQILE 741_ GEIHM 746_ GGQEH 751_ FYMET 756_ QSMLV 761_ VPKGE 766_ DQEMD 771_ VYVST 776_ QFPKY 781_ IQDIV 786_ ASTLK 791_ LPANK 796_ VMCHV 801_ RRVGG 806_ AFGGK 811_ VLKTG 816_ IIAAV 821_ TAFAA 826_ NKHGR 831_ AVRCV 836_ LERGE 841_ DMLIT 846_ GGRHP 851_ YLGKY 856_ KAGFM 861_ NDGRI 866_ LALDM 871_ EHYSN 876_ AGASL 881_ DESLF 886_ VIEMG 891_ LLKMD 896_ NAYKF 901_ PNLRC 906_ RGWAC 911_ RTNLP 916_ SNTAF 921_ RGFGF 926_ PQAAL 931_ ITESC 936_ ITEVA 941_ AKCGL 946_ SPEKV 951_ RIINM 956_ YKEID 961_ QTPYK 966_ QEINA 971_ KNLIQ 976_ CWREC 981_ MAMSS 986_ YSLRK 991_ VAVEK 996_ FNAEN 1001_ YWKKK 1006_ GLAMV 1011_ PLKFP 1016_ VGLGS 1021_ RAAGQ 1026_ AAALV 1031_ HIYLD 1036_ GSVLV 1041_ THGGI 1046_ EMGQG 1051_ VHTKM 1056_ IQVVS 1061_ RELRM 1066_ PMSNV 1071_ HLRGT 1076_ STETV 1081_ PNANI 1086_ SGGSV 1091_ VADLN 1096_ GLAVK 1101_ DACQT 1106_ LLKRL 1111_ EPIIS 1116_ KNPKG 1121_ TWKDW 1126_ AQTAF 1131_ DESIN 1136_ LSAVG 1141_ YFRGY 1146_ ESDMN 1151_ WEKGE 1156_ GQPFE 1161_ YFVYG 1166_ AACSE 1171_ VEIDC 1176_ LTGDH 1181_ KNIRT 1186_ DIVMD 1191_ VGCSI 1196_ NPAID 1201_ IGQIE 1206_ GAFIQ 1211_ GMGLY 1216_ TIEEL 1221_ NYSPQ 1226_ GILHT 1231_ RGPDQ 1236_ YKIPA 1241_ ICDMP 1246_ TELHI 1251_ ALLPP 1256_ SQNSN 1261_ TLYSS 1266_ KGLGE 1271_ SGVFL 1276_ GCSVF 1281_ FAIHD 1286_ AVSAA 1291_ RQERG 1296_ LHGPL 1301_ TLNSP 1306_ LTPEK 1311_ IRMAC 1316_ EDKFT 1321_ KMIPR 1326_ DEPGS 1331_YVPWN
1: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis