Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
1_MDHTE 6_ GSPAE 11_ EPPAH 16_ APSPG 21_ KFGER 26_ PPPKR 31_ LTREA 36_ MRNYL 41_ KERGD 46_ QTVLI 51_ LHAKV 56_ AQKSY 61_ GNEKR 66_ FFCPP 71_ PCVYL 76_ MGSGW 81_ KKKKE 86_ QMERD 91_ GCSEQ 96_ ESQPC 101_ AFIGI 106_ GNSDQ 111_ EMQQL 116_ NLEGK 121_ NYCTA 126_ KTLYI 131_ SDSDK 136_ RKHFM 141_ LSVKM 146_ FYGNS 151_ DDIGV 156_ FLSKR 161_ IKVIS 166_ KPSKK 171_ KQSLK 176_ NADLC 181_ IASGT 186_ KVALF 191_ NRLRS 196_ QTVST 201_ RYLHV 206_ EGGNF 211_ HASSQ 216_ QWGAF 221_ FIHLL 226_ DDDES 231_ EGEEF 236_ TVRDG 241_ YIHYG 246_ QTVKL 251_ VCSVT 256_ GMALP 261_ RLIIR 266_ KVDKQ 271_ TALLD 276_ ADDPV 281_ SQLHK 286_ CAFYL 291_ KDTER 296_ MYLCL 301_ SQERI 306_ IQFQA 311_ TPCPK 316_ EPNKE 321_ MINDG 326_ ASWTI 331_ ISTDK 336_ AEYTF 341_ YEGMG 346_ PVLAP 351_ VTPVP 356_ VVESL 361_ QLNGG 366_ GDVAM 371_ LELTG 376_ QNFTP 381_ NLRVW 386_ FGDVE 391_ AETMY 396_ RCGES 401_ MLCVV 406_ PDISA 411_ FREGW 416_ RWVRQ 421_ PVQVP 426_ VTLVR 431_ NDGII 436_ YSTSL 441_ TFTYT 446_ PEPGP 451_ RPHCS 456_ AAGAI 461_ LRANS 466_ SQVPP 471_ NESNT 476_ NSEGS 481_ YTNAS 486_ TNSTS 491_VTSST
1: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity)