Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C)
1_MGRKK 6_ IQITR 11_ IMDER 16_ NRQVT 21_ FTKRK 26_ FGLMK 31_ KAYEL 36_ SVLCD 41_ CEIAL 46_ IIFNS 51_ TNKLF 56_ QYAST 61_ DMDKV 66_ LLKYT 71_ EYNEP 76_ HESRT 81_ NSDIV 86_ ETLRK 91_ KGLNG 96_ CDSPD 101_ PDADD 106_ SVGHS 111_ PESED 116_ KYRKI 121_ NEDID 126_ LMISR 131_ QRLCA 136_ VPPPN 141_ FEMPV 146_ SIPVS 151_ SHNSL 156_ VYSNP 161_ VSSLG 166_ NPNLL 171_ PLAHP 176_ SLQRN 181_ SMSPG 186_ VTHRP 191_ PSAGN 196_ TGGLM 201_ GGDLT 206_ SGAGT 211_ SAGNG 216_ YGNPR 221_ NSPGL 226_ LVSPG 231_ NLNKN 236_ MQAKS 241_ PPPMN 246_ LGMNN 251_ RKPDL 256_ RVLIP 261_ PGSKN 266_ TMPSV 271_ SEDVD 276_ LLLNQ 281_ RINNS 286_ QSAQS 291_ LATPV 296_ VSVAT 301_ PTLPG 306_ QGMGG 311_ YPSAI 316_ STTYG 321_ TEYSL 326_ SSADL 331_ SSLSG 336_ FNTAS 341_ ALHLG 346_ SVTGW 351_ QQQHL 356_ HNMPP 361_ SALSQ 366_ LGACT 371_ STHLS 376_ QSSNL 381_ SLPST 386_ QSLNI 391_ KSEPV 396_ SPPRD 401_ RTTTP 406_ SRYPQ 411_ HTRHE 416_ AGRSP 421_ VDSLS 426_ SCSSS 431_ YDGSD 436_ REDHR 441_ NEFHS 446_ PIGLT 451_ RPSPD 456_ ERESP 461_ SVKRM 466_RLSEG
1: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1