Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
1_MALRR 6_ SMGRP 11_ GLPPL 16_ PLPPP 21_ PRLGL 26_ LLAAL 31_ ASLLL 36_ PESAA 41_ AGLKL 46_ MGAPV 51_ KLTVS 56_ QGQPV 61_ KLNCS 66_ VEGME 71_ EPDIQ 76_ WVKDG 81_ AVVQN 86_ LDQLY 91_ IPVSE 96_ QHWIG 101_ FLSLK 106_ SVERS 111_ DAGRY 116_ WCQVE 121_ DGGET 126_ EISQP 131_ VWLTV 136_ EGVPF 141_ FTVEP 146_ KDLAV 151_ PPNAP 156_ FQLSC 161_ EAVGP 166_ PEPVT 171_ IVWWR 176_ GTTKI 181_ GGPAP 186_ SPSVL 191_ NVTGV 196_ TQSTM 201_ FSCEA 206_ HNLKG 211_ LASSR 216_ TATVH 221_ LQALP 226_ AAPFN 231_ ITVTK 236_ LSSSN 241_ ASVAW 246_ MPGAD 251_ GRALL 256_ QSCTV 261_ QVTQA 266_ PGGWE 271_ VLAVV 276_ VPVPP 281_ FTCLL 286_ RDLVP 291_ ATNYS 296_ LRVRC 301_ ANALG 306_ PSPYA 311_ DWVPF 316_ QTKGL 321_ APASA 326_ PQNLH 331_ AIRTD 336_ SGLIL 341_ EWEEV 346_ IPEAP 351_ LEGPL 356_ GPYKL 361_ SWVQD 366_ NGTQD 371_ ELTVE 376_ GTRAN 381_ LTGWD 386_ PQKDL 391_ IVRVC 396_ VSNAV 401_ GCGPW 406_ SQPLV 411_ VSSHD 416_ RAGQQ 421_ GPPHS 426_ RTSWV 431_ PVVLG 436_ VLTAL 441_ VTAAA 446_ LALIL 451_ LRKRR 456_ KETRF 461_ GQAFD 466_ SVMAR 471_ GEPAV 476_ HFRAA 481_ RSFNR 486_ ERPER 491_ IEATL 496_ DSLGI 501_ SDELK 506_ EKLED 511_ VLIPE 516_ QQFTL 521_ GRMLG 526_ KGEFG 531_ SVREA 536_ QLKQE 541_ DGSFV 546_ KVAVK 551_ MLKAD 556_ IIASS 561_ DIEEF 566_ LREAA 571_ CMKEF 576_ DHPHV 581_ AKLVG 586_ VSLRS 591_ RAKGR 596_ LPIPM 601_ VILPF 606_ MKHGD 611_ LHAFL 616_ LASRI 621_ GENPF 626_ NLPLQ 631_ TLIRF 636_ MVDIA 641_ CGMEY 646_ LSSRN 651_ FIHRD 656_ LAARN 661_ CMLAE 666_ DMTVC 671_ VADFG 676_ LSRKI 681_ YSGDY 686_ YRQGC 691_ ASKLP 696_ VKWLA 701_ LESLA 706_ DNLYT 711_ VQSDV 716_ WAFGV 721_ TMWEI 726_ MTRGQ 731_ TPYAG 736_ IENAE 741_ IYNYL 746_ IGGNR 751_ LKQPP 756_ ECMED 761_ VYDLM 766_ YQCWS 771_ ADPKQ 776_ RPSFT 781_ CLRME 786_ LENIL 791_ GQLSV 796_ LSASQ 801_ DPLYI 806_ NIERA 811_ EEPTA 816_ GGSLE 821_ LPGRD 826_ QPYSG 831_ AGDGS 836_ GMGAV 841_ GGTPS 846_ DCRYI 851_ LTPGG 856_ LAEQP 861_ GQAEH 866_ QPESP 871_ LNETQ 876_ RLLLL 881_QQGLL
1: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3
2: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope
3: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope