Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3)
1_MSDDF 6_ LWFEG 11_ IAFPT 16_ MGFRS 21_ ETLRK 26_ VRDEF 31_ VIRDE 36_ DVIIL 41_ TYPKS 46_ GTNWL 51_ AEILC 56_ LMHSK 61_ GDAKW 66_ IQSVP 71_ IWERS 76_ PWVES 81_ EIGYT 86_ ALSET 91_ ESPRL 96_ FSSHL 101_ PIQLF 106_ PKSFF 111_ SSKAK 116_ VIYLM 121_ RNPRD 126_ VLVSG 131_ YFFWK 136_ NMKFI 141_ KKPKS 146_ WEEYF 151_ EWFCQ 156_ GTVLY 161_ GSWFD 166_ HIHGW 171_ MPMRE 176_ EKNFL 181_ LLSYE 186_ ELKQD 191_ TGRTI 196_ EKICQ 201_ FLGKT 206_ LEPEE 211_ LNLIL 216_ KNSSF 221_ QSMKE 226_ NKMSN 231_ YSLLS 236_ VDYVV 241_ DKAQL 246_ LRKGV 251_ SGDWK 256_ NHFTV 261_ AQAED 266_ FDKLF 271_ QEKMA 276_DLPRE
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:14573603, PubMed:19589875, PubMed:21187059). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity)