E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
1_MTTPA 6_ NAQNA 11_ SKTWE 16_ LSLYE 21_ LHRTP 26_ QEAIM 31_ DGTEI 36_ AVSPR 41_ SLHSE 46_ LMCPI 51_ CLDML 56_ KNTMT 61_ TKECL 66_ HRFCS 71_ DCIVT 76_ ALRSG 81_ NKECP 86_ TCRKK 91_ LVSKR 96_ SLRPD 101_ PNFDA 106_ LISKI 111_ YPSRE 116_ EYEAH 121_ QDRVL 126_ IRLSR 131_ LHNQQ 136_ ALSSS 141_ IEEGL 146_ RMQAM 151_ HRAQR 156_ VRRPI 161_ PGSDQ 166_ TTTMS 171_ GGEGE 176_ PGEGE 181_ GDGED 186_ VSSDS 191_ APDSA 196_ PGPAP 201_ KRPRG 206_ GGAGG 211_ SSVGT 216_ GGGGT 221_ GGVGG 226_ GAGSE 231_ DSGDR 236_ GGTLG 241_ GGTLG 246_ PPSPP 251_ GAPSP 256_ PEPGG 261_ EIELV 266_ FRPHP 271_ LLVEK 276_ GEYCQ 281_ TRYVK 286_ TTGNA 291_ TVDHL 296_ SKYLA 301_ LRIAL 306_ ERRQQ 311_ QEAGE 316_ PGGPG 321_ GGASD 326_ TGGPD 331_ GCGGE 336_ GGGAG 341_ GGDGP 346_ EEPAL 351_ PSLEG 356_ VSEKQ 361_ YTIYI 366_ APGGG 371_ AFTTL 376_ NGSLT 381_ LELVN 386_ EKFWK 391_ VSRPL 396_ ELCYA 401_PTKDP
1: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity