DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)
1_MAMQM 6_ QLEAN 11_ ADTSV 16_ EEESF 21_ GPQPI 26_ SRLEQ 31_ CGINA 36_ NDVKK 41_ LEEAG 46_ FHTVE 51_ AVAYA 56_ PKKEL 61_ INIKG 66_ ISEAK 71_ ADKIL 76_ AEAAK 81_ LVPMG 86_ FTTAT 91_ EFHQR 96_ RSEII 101_ QITTG 106_ SKELD 111_ KLLQG 116_ GIETG 121_ SITEM 126_ FGEFR 131_ TGKTQ 136_ ICHTL 141_ AVTCQ 146_ LPIDR 151_ GGGEG 156_ KAMYI 161_ DTEGT 166_ FRPER 171_ LLAVA 176_ ERYGL 181_ SGSDV 186_ LDNVA 191_ YARAF 196_ NTDHQ 201_ TQLLY 206_ QASAM 211_ MVESR 216_ YALLI 221_ VDSAT 226_ ALYRT 231_ DYSGR 236_ GELSA 241_ RQMHL 246_ ARFLR 251_ MLLRL 256_ ADEFG 261_ VAVVI 266_ TNQVV 271_ AQVDG 276_ AAMFA 281_ ADPKK 286_ PIGGN 291_ IIAHA 296_ STTRL 301_ YLRKG 306_ RGETR 311_ ICKIY 316_ DSPCL 321_ PEAEA 326_ MFAIN 331_ADGVG
1: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:22325354, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:32640219). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:38459011). Recruited to resolve stalled replication forks during replication stress (PubMed:27797818, PubMed:31844045). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (PubMed:12442171, PubMed:24141787). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (PubMed:20413593). Also involved in interstrand cross-link repair (PubMed:26253028)