Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
1_MSSGN 6_ AKIGH 11_ PAPNF 16_ KATAV 21_ MPDGQ 26_ FKDIS 31_ LSDYK 36_ GKYVV 41_ FFFYP 46_ LDFTF 51_ VCPTE 56_ IIAFS 61_ DRAEE 66_ FKKLN 71_ CQVIG 76_ ASVDS 81_ HFCHL 86_ AWVNT 91_ PKKQG 96_ GLGPM 101_ NIPLV 106_ SDPKR 111_ TIAQD 116_ YGVLK 121_ ADEGI 126_ SFRGL 131_ FIIDD 136_ KGILR 141_ QITVN 146_ DLPVG 151_ RSVDE 156_ TLRLV 161_ QAFQF 166_ TDKHG 171_ EVCPA 176_ GWKPG 181_ SDTIK 186_ PDVQK 191_SKEYF
1: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)