Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
1_MSARA 6_ AAAKS 11_ TAMEE 16_ TAIWE 21_ QHTVT 26_ LHRAP 31_ GFGFG 36_ IAISG 41_ GRDNP 46_ HFQSG 51_ ETSIV 56_ ISDVL 61_ KGGPA 66_ EGQLQ 71_ ENDRV 76_ AMVNG 81_ VSMDN 86_ VEHAF 91_ AVQQL 96_ RKSGK 101_ NAKIT 106_ IRRKK 111_ KVQIP 116_ VSRPD 121_ PEPVS 126_ DNEED 131_ SYDEE 136_ IHDPR 141_ SGRSG 146_ VVNRR 151_ SEKIW 156_ PRDRS 161_ ASRER 166_ SLSPR 171_ SDRRS 176_ VASSQ 181_ PAKPT 186_ KVTLV 191_ KSRKN 196_ EEYGL 201_ RLASH 206_ IFVKE 211_ ISQDS 216_ LAARD 221_ GNIQE 226_ GDVVL 231_ KINGT 236_ VTENM 241_ SLTDA 246_ KTLIE 251_ RSKGK 256_ LKMVV 261_ QRDER 266_ ATLLN 271_ VPDLS 276_ DSIHS 281_ ANASE 286_ RDDIS 291_ EIQSL 296_ ASDHS 301_ GRSHD 306_ RPPRR 311_ SRSRS 316_ PDQRS 321_ EPSDH 326_ SRHSP 331_ QQPSN 336_ GSLRS 341_ RDEER 346_ ISKPG 351_ AVSTP 356_ VKHAD 361_ DHTPK 366_ TVEEV 371_ TVERN 376_ EKQTP 381_ SLPEP 386_ KPVYA 391_ QVGQP 396_ DVDLP 401_ VSPSD 406_ GVLPN 411_ STHED 416_ GILRP 421_ SMKLV 426_ KFRKG 431_ DSVGL 436_ RLAGG 441_ NDVGI 446_ FVAGV 451_ LEDSP 456_ AAKEG 461_ LEEGD 466_ QILRV 471_ NNVDF 476_ TNIIR 481_ EEAVL 486_ FLLDL 491_ PKGEE 496_ VTILA 501_ QKKKD 506_ VYRRI 511_ VESDV 516_ GDSFY 521_ IRTHF 526_ EYEKE 531_ SPYGL 536_ SFNKG 541_ EVFRV 546_ VDTLY 551_ NGKLG 556_ SWLAI 561_ RIGKN 566_ HKEVE 571_ RGIIP 576_ NKNRA 581_ EQLAS 586_ VQYTL 591_ PKTAG 596_ GDRAD 601_ FWRFR 606_ GLRSS 611_ KRNLR 616_ KSRED 621_ LSAQP 626_ VQTKF 631_ PAYER 636_ VVLRE 641_ AGFLR 646_ PVTIF 651_ GPIAD 656_ VAREK 661_ LAREE 666_ PDIYQ 671_ IAKSE 676_ PRDAG 681_ TDQRS 686_ SGIIR 691_ LHTIK 696_ QIIDQ 701_ DKHAL 706_ LDVTP 711_ NAVDR 716_ LNYAQ 721_ WYPIV 726_ VFLNP 731_ DSKQG 736_ VKTMR 741_ MRLCP 746_ ESRKS 751_ ARKLY 756_ ERSHK 761_ LRKNN 766_ HHLFT 771_ TTINL 776_ NSMND 781_ GWYGA 786_ LKEAI 791_ QQQQN 796_ QLVWV 801_ SEGKA 806_ DGATS 811_ DDLDL 816_ HDDRL 821_ SYLSA 826_ PGSEY 831_ SMYST 836_ DSRHT 841_ SDYED 846_ TDTEG 851_ GAYTD 856_ QELDE 861_ TLNDE 866_ VGTPP 871_ ESAIT 876_ RSSEP 881_ VREDS 886_ SGMHH 891_ ENQTY 896_ PPYSP 901_ QAQPQ 906_ PIHRI 911_ DSPGF 916_ KPASQ 921_ QKAEA 926_ SSPVP 931_ YLSPE 936_ TNPAS 941_ STSAV 946_ NHNVN 951_ LTNVR 956_ LEEPT 961_ PAPST 966_ SYSPQ 971_ ADSLR 976_ TPSTE 981_ AAHIM 986_ LRDQE 991_ PSLSS 996_ HVDPT 1001_ KVYRK 1006_ DPYPE 1011_ EMMRQ 1016_ NHVLK 1021_ QPAVS 1026_ HPGHR 1031_ PDKEP 1036_ NLTYE 1041_ PQLPY 1046_ VEKQA 1051_ SRDLE 1056_ QPTYR 1061_ YESSS 1066_ YTDQF 1071_ SRNYE 1076_ HRLRY 1081_ EDRVP 1086_ MYEEQ 1091_ WSYYD 1096_ DKQPY 1101_ PSRPP 1106_ FDNQH 1111_ SQDLD 1116_ SRQHP 1121_ EESSE 1126_ RGYFP 1131_ RFEEP 1136_ APLSY 1141_ DSRPR 1146_ YEQAP 1151_ RASAL 1156_ RHEEQ 1161_ PAPGY 1166_ DTHGR 1171_ LRPEA 1176_ QPHPS 1181_ AGPKP 1186_ AESKQ 1191_ YFEQY 1196_ SRSYE 1201_ QVPPQ 1206_ GFTSR 1211_ AGHFE 1216_ PLHGA 1221_ AAVPP 1226_ LIPSS 1231_ QHKPE 1236_ ALPSN 1241_ TKPLP 1246_ PPPTQ 1251_ TEEEE 1256_ DPAMK 1261_ PQSVL 1266_ TRVKM 1271_ FENKR 1276_ SASLE 1281_ TKKDV 1286_ NDTGS 1291_ FKPPE 1296_ VASKP 1301_ SGAPI 1306_ IGPKP 1311_ TSQNQ 1316_ FSEHD 1321_ KTLYR 1326_ IPEPQ 1331_ KPQLK 1336_ PPEDI 1341_ VRSNH 1346_ YDPEE 1351_ DEEYY 1356_ RKQLS 1361_ YFDRR 1366_ SFENK 1371_ PPAHI 1376_ AASHL 1381_ SEPAK 1386_ PAHSQ 1391_ NQSNF 1396_ SSYSS 1401_ KGKPP 1406_ EADGV 1411_ DRSFG 1416_ EKRYE 1421_ PIQAT 1426_ PPPPP 1431_ LPSQY 1436_ AQPSQ 1441_ PVTSA 1446_ SLHIH 1451_ SKGAH 1456_ GEGNS 1461_ VSLDF 1466_ QNSLV 1471_ SKPDP 1476_ PPSQN 1481_ KPATF 1486_ RPPNR 1491_ EDTAQ 1496_ AAFYP 1501_ QKSFP 1506_ DKAPV 1511_ NGTEQ 1516_ TQKTV 1521_ TPAYN 1526_ RFTPK 1531_ PYTSS 1536_ ARPFE 1541_ RKFES 1546_ PKFNH 1551_ NLLPS 1556_ ETAHK 1561_ PDLSS 1566_ KTPTS 1571_ PKTLV 1576_ KSHSL 1581_ AQPPE 1586_ FDSGV 1591_ ETFSI 1596_ HAEKP 1601_ KYQIN 1606_ NISTV 1611_ PKAIP 1616_ VSPSA 1621_ VEEDE 1626_ DEDGH 1631_ TVVAT 1636_ ARGIF 1641_ NSNGG 1646_ VLSSI 1651_ ETGVS 1656_ IIIPQ 1661_ GAIPE 1666_ GVEQE 1671_ IYFKV 1676_ CRDNS 1681_ ILPPL 1686_ DKEKG 1691_ ETLLS 1696_ PLVMC 1701_ GPHGL 1706_ KFLKP 1711_ VELRL 1716_ PHCDP 1721_ KTWQN 1726_ KCLPG 1731_ DPNYL 1736_ VGANC 1741_VSVLI
1: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity)