Sodium channel subunit beta-1
1_MGRLL 6_ ALVVG 11_ AALVS 16_ SACGG 21_ CVEVD 26_ SETEA 31_ VYGMT 36_ FKILC 41_ ISCKR 46_ RSETN 51_ AETFT 56_ EWTFR 61_ QKGTE 66_ EFVKI 71_ LRYEN 76_ EVLQL 81_ EEDER 86_ FEGRV 91_ VWNGS 96_ RGTKD 101_ LQDLS 106_ IFITN 111_ VTYNH 116_ SGDYE 121_ CHVYR 126_ LLFFE 131_ NYEHN 136_ TSVVK 141_ KIHIE 146_ VVDKA 151_ NRDMA 156_ SIVSE 161_ IMMYV 166_ LIVVL 171_ TIWLV 176_ AEMIY 181_ CYKKI 186_ AAATE 191_ TAAQE 196_ NASEY 201_ LAITS 206_ ESKEN 211_CTGVQ
1: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14622265, PubMed:15525788, PubMed:18464934, PubMed:19710327, PubMed:29992740, PubMed:36696443, PubMed:8125980, PubMed:8394762). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:15525788, PubMed:19710327, PubMed:29992740). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (PubMed:14622265, PubMed:15525788, PubMed:18464934, PubMed:30765606, PubMed:36696443, PubMed:8125980, PubMed:8394762)
2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth (PubMed:21994374). Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265)