Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
1_MSQSN 6_ RELVV 11_ DFLSY 16_ KLSQK 21_ GYSWS 26_ QFSDV 31_ EENRT 36_ EAPEG 41_ TESEM 46_ ETPSA 51_ INGNP 56_ SWHLA 61_ DSPAV 66_ NGATG 71_ HSSSL 76_ DAREV 81_ IPMAA 86_ VKQAL 91_ REAGD 96_ EFELR 101_ YRRAF 106_ SDLTS 111_ QLHIT 116_ PGTAY 121_ QSFEQ 126_ VVNEL 131_ FRDGV 136_ NWGRI 141_ VAFFS 146_ FGGAL 151_ CVESV 156_ DKEMQ 161_ VLVSR 166_ IAAWM 171_ ATYLN 176_ DHLEP 181_ WIQEN 186_ GGWDT 191_ FVELY 196_ GNNAA 201_ AESRK 206_ GQERF 211_ NRWFL 216_ TGMTV 221_ AGVVL 226_LGSLF
1: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis
2: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)
3: Isoform Bcl-X(S) promotes apoptosis