Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)
1_MAEDK 6_ SKRDS 11_ IEMSM 16_ KGCQT 21_ NNGFV 26_ HNEDI 31_ LEQTP 36_ DPGSS 41_ TDNLK 46_ HSTRG 51_ ILGSQ 56_ EPDFK 61_ GVQPY 66_ AGMPK 71_ EVLFQ 76_ FSGQA 81_ RYRIP 86_ REILF 91_ WLTVA 96_ SVLVL 101_ IAATI 106_ AIIAL 111_ SPKCL 116_ DWWQE 121_ GPMYQ 126_ IYPRS 131_ FKDSN 136_ KDGNG 141_ DLKGI 146_ QDKLD 151_ YITAL 156_ NIKTV 161_ WITSF 166_ YKSSL 171_ KDFRY 176_ GVEDF 181_ REVDP 186_ IFGTM 191_ EDFEN 196_ LVAAI 201_ HDKGL 206_ KLIID 211_ FIPNH 216_ TSDKH 221_ IWFQL 226_ SRTRT 231_ GKYTD 236_ YYIWH 241_ DCTHE 246_ NGKTI 251_ PPNNW 256_ LSVYG 261_ NSSWH 266_ FDEVR 271_ NQCYF 276_ HQFMK 281_ EQPDL 286_ NFRNP 291_ DVQEE 296_ IKEIL 301_ RFWLT 306_ KGVDG 311_ FSLDA 316_ VKFLL 321_ EAKHL 326_ RDEIQ 331_ VNKTQ 336_ IPDTV 341_ TQYSE 346_ LYHDF 351_ TTTQV 356_ GMHDI 361_ VRSFR 366_ QTMDQ 371_ YSTEP 376_ GRYRF 381_ MGTEA 386_ YAESI 391_ DRTVM 396_ YYGLP 401_ FIQEA 406_ DFPFN 411_ NYLSM 416_ LDTVS 421_ GNSVY 426_ EVITS 431_ WMENM 436_ PEGKW 441_ PNWMI 446_ GGPDS 451_ SRLTS 456_ RLGNQ 461_ YVNVM 466_ NMLLF 471_ TLPGT 476_ PITYY 481_ GEEIG 486_ MGNIV 491_ AANLN 496_ ESYDI 501_ NTLRS 506_ KSPMQ 511_ WDNSS 516_ NAGFS 521_ EASNT 526_ WLPTN 531_ SDYHT 536_ VNVDV 541_ QKTQP 546_ RSALK 551_ LYQDL 556_ SLLHA 561_ NELLL 566_ NRGWF 571_ CHLRN 576_ DSHYV 581_ VYTRE 586_ LDGID 591_ RIFIV 596_ VLNFG 601_ ESTLL 606_ NLHNM 611_ ISGLP 616_ AKMRI 621_ RLSTN 626_ SADKG 631_ SKVDT 636_ SGIFL 641_ DKGEG 646_ LIFEH 651_ NTKNL 656_ LHRQT 661_ AFRDR 666_ CFVSN 671_ RACYS 676_SVLNI
1: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:10588648, PubMed:11318953, PubMed:16609684, PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:7686906, PubMed:8486766, PubMed:8663184, PubMed:8663357). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (PubMed:10588648, PubMed:11318953, PubMed:16609684, PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:7686906, PubMed:8486766, PubMed:8663184, PubMed:8663357). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity)