DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)
1_MSLRS 6_ GGRRR 11_ ADPGA 16_ DGEAS 21_ RDDGA 26_ TSSVS 31_ ALKRL 36_ ERSQW 41_ TDKMD 46_ LRFGF 51_ ERLKE 56_ PGEKT 61_ GWLIN 66_ MHPTE 71_ ILDED 76_ KRLGS 81_ AVDYY 86_ FIQDD 91_ GSRFK 96_ VALPY 101_ KPYFY 106_ IATRK 111_ GCERE 116_ VSSFL 121_ SKKFQ 126_ GKIAK 131_ VETVP 136_ KEDLD 141_ LPNHL 146_ VGLKR 151_ NYIRL 156_ SFHTV 161_ EDLVK 166_ VRKEI 171_ SPAVK 176_ KNREQ 181_ DHASD 186_ AYTAL 191_ LSSVL 196_ QRGGV 201_ ITDEE 206_ ETSKK 211_ IADQL 216_ DNIVD 221_ MREYD 226_ VPYHI 231_ RLSID 236_ LKIHV 241_ AHWYN 246_ VRYRG 251_ NAFPV 256_ EITRR 261_ DDLVE 266_ RPDPV 271_ VLAFD 276_ IETTK 281_ LPLKF 286_ PDAET 291_ DQIMM 296_ ISYMI 301_ DGQGY 306_ LITNR 311_ EIVSE 316_ DIEDF 321_ EFTPK 326_ PEYEG 331_ PFCVF 336_ NEPDE 341_ AHLIQ 346_ RWFEH 351_ VQETK 356_ PTIMV 361_ TYNGD 366_ FFDWP 371_ FVEAR 376_ AAVHG 381_ LSMQQ 386_ EIGFQ 391_ KDSQG 396_ EYKAP 401_ QCIHM 406_ DCLRW 411_ VKRDS 416_ YLPVG 421_ SHNLK 426_ AAAKA 431_ KLGYD 436_ PVELD 441_ PEDMC 446_ RMATE 451_ QPQTL 456_ ATYSV 461_ SDAVA 466_ TYYLY 471_ MKYVH 476_ PFIFA 481_ LCTII 486_ PMEPD 491_ EVLRK 496_ GSGTL 501_ CEALL 506_ MVQAF 511_ HANII 516_ FPNKQ 521_ EQEFN 526_ KLTDD 531_ GHVLD 536_ SETYV 541_ GGHVE 546_ ALESG 551_ VFRSD 556_ IPCRF 561_ RMNPA 566_ AFDFL 571_ LQRVE 576_ KTLRH 581_ ALEEE 586_ EKVPV 591_ EQVTN 596_ FEEVC 601_ DEIKS 606_ KLASL 611_ KDVPS 616_ RIECP 621_ LIYHL 626_ DVGAM 631_ YPNII 636_ LTNRL 641_ QPSAM 646_ VDEAT 651_ CAACD 656_ FNKPG 661_ ANCQR 666_ KMAWQ 671_ WRGEF 676_ MPASR 681_ SEYHR 686_ IQHQL 691_ ESEKF 696_ PPLFP 701_ EGPAR 706_ AFHEL 711_ SREEQ 716_ AKYEK 721_ RRLAD 726_ YCRKA 731_ YKKIH 736_ ITKVE 741_ ERLTT 746_ ICQRE 751_ NSFYV 756_ DTVRA 761_ FRDRR 766_ YEFKG 771_ LHKVW 776_ KKKLS 781_ AAVEV 786_ GDAAE 791_ VKRCK 796_ NMEVL 801_ YDSLQ 806_ LAHKC 811_ ILNSF 816_ YGYVM 821_ RKGAR 826_ WYSME 831_ MAGIV 836_ CFTGA 841_ NIITQ 846_ ARELI 851_ EQIGR 856_ PLELD 861_ TDGIW 866_ CVLPN 871_ SFPEN 876_ FVFKT 881_ TNVKK 886_ PKVTI 891_ SYPGA 896_ MLNIM 901_ VKEGF 906_ TNDQY 911_ QELAE 916_ PSSLT 921_ YVTRS 926_ ENSIF 931_ FEVDG 936_ PYLAM 941_ ILPAS 946_ KEEGK 951_ KLKKR 956_ YAVFN 961_ EDGSL 966_ AELKG 971_ FEVKR 976_ RGELQ 981_ LIKIF 986_ QSSVF 991_ EAFLK 996_ GSTLE 1001_ EVYGS 1006_ VAKVA 1011_ DYWLD 1016_ VLYSK 1021_ AANMP 1026_ DSELF 1031_ ELISE 1036_ NRSMS 1041_ RKLED 1046_ YGEQK 1051_ STSIS 1056_ TAKRL 1061_ AEFLG 1066_ DQMVK 1071_ DAGLS 1076_ CRYII 1081_ SRKPE 1086_ GSPVT 1091_ ERAIP 1096_ LAIFQ 1101_ AEPTV 1106_ RKHFL 1111_ RKWLK 1116_ SSSLQ 1121_ DFDIR 1126_ AILDW 1131_ DYYIE 1136_ RLGSA 1141_ IQKII 1146_ TIPAA 1151_ LQQVK 1156_ NPVPR 1161_ VKHPD 1166_ WLHKK 1171_ LLEKN 1176_ DVYKQ 1181_ KKISE 1186_ LFTLE 1191_ GRRQV 1196_ TMAEA 1201_ SEDSP 1206_ RPSAP 1211_ DMEDF 1216_ GLVKL 1221_ PHPAA 1226_ PVTVK 1231_ RKRVL 1236_ WESQE 1241_ ESQDL 1246_ TPTVP 1251_ WQEIL 1256_ GQPPA 1261_ LGTSQ 1266_ EEWLV 1271_ WLRFH 1276_ KKKWQ 1281_ LQARQ 1286_ RLARR 1291_ KRQRL 1296_ ESAEG 1301_ VLRPG 1306_ AIRDG 1311_ PATGL 1316_ GSFLR 1321_ RTARS 1326_ ILDLP 1331_ WQIVQ 1336_ ISETS 1341_ QAGLF 1346_ RLWAL 1351_ VGSDL 1356_ HCIRL 1361_ SIPRV 1366_ FYVNQ 1371_ RVAKA 1376_ EEGAS 1381_ YRKVN 1386_ RVLPR 1391_ SNMVY 1396_ NLYEY 1401_ SVPED 1406_ MYQEH 1411_ INEIN 1416_ AELSA 1421_ PDIEG 1426_ VYETQ 1431_ VPLLF 1436_ RALVH 1441_ LGCVC 1446_ VVNKQ 1451_ LVRHL 1456_ SGWEA 1461_ ETFAL 1466_ EHLEM 1471_ RSLAQ 1476_ FSYLE 1481_ PGSIR 1486_ HIYLY 1491_ HHAQA 1496_ HKALF 1501_ GIFIP 1506_ SQRRA 1511_ SVFVL 1516_ DTVRS 1521_ NQMPS 1526_ LGALY 1531_ SAEHG 1536_ LLLEK 1541_ VGPEL 1546_ LPPPK 1551_ HTFEV 1556_ RAETD 1561_ LKTIC 1566_ RAIQR 1571_ FLLAY 1576_ KEERR 1581_ GPTLI 1586_ AVQSS 1591_ WELKR 1596_ LASEI 1601_ PVLEE 1606_ FPLVP 1611_ ICVAD 1616_ KINYG 1621_ VLDWQ 1626_ RHGAR 1631_ RMIRH 1636_ YLNLD 1641_ TCLSQ 1646_ AFEMS 1651_ RYFHI 1656_ PIGNL 1661_ PEDIS 1666_ TFGSD 1671_ LFFAR 1676_ HLQRH 1681_ NHLLW 1686_ LSPTA 1691_ RPDLG 1696_ GKEAD 1701_ DNCLV 1706_ MEFDD 1711_ QATVE 1716_ INSSG 1721_ CYSTV 1726_ CVELD 1731_ LQNLA 1736_ VNTIL 1741_ QSHHV 1746_ NDMEG 1751_ ADSMG 1756_ ISFDV 1761_ IQQAS 1766_ LEDMI 1771_ TGGQA 1776_ ASAPA 1781_ SYDET 1786_ ALCSN 1791_ TFRIL 1796_ KSMVV 1801_ GWVKE 1806_ ITQYH 1811_ NIYAD 1816_ NQVMH 1821_ FYRWL 1826_ RSPSS 1831_ LLHDP 1836_ ALHRT 1841_ LHNMM 1846_ KKLFL 1851_ QLIAE 1856_ FKRLG 1861_ SSVIY 1866_ ANFNR 1871_ IILCT 1876_ KKRRV 1881_ EDAIA 1886_ YVEYI 1891_ TSSIH 1896_ SKETF 1901_ HSLTI 1906_ SFSRC 1911_ WEFLL 1916_ WMDPS 1921_ NYGGI 1926_ KGKVS 1931_ SRIHC 1936_ GLQDS 1941_ QKAGG 1946_ AEDEQ 1951_ ENEDD 1956_ EEERD 1961_ GEEEE 1966_ EAEES 1971_ NVEDL 1976_ LENNW 1981_ NILQF 1986_ LPQAA 1991_ SCQNY 1996_ FLMIV 2001_ SAYIV 2006_ AVYHC 2011_ MKDGL 2016_ RRSAP 2021_ GSTPV 2026_ RRRGA 2031_ SQLSQ 2036_ EAEGA 2041_ VGALP 2046_ GMITF 2051_ SQDYV 2056_ ANELT 2061_ QSFFT 2066_ ITQKI 2071_ QKKVT 2076_ GSRNS 2081_ TELSE 2086_ MFPVL 2091_ PGSHL 2096_ LLNNP 2101_ ALEFI 2106_ KYVCK 2111_ VLSLD 2116_ TNITN 2121_ QVNKL 2126_ NRDLL 2131_ RLVDV 2136_ GEFSE 2141_ EAQFR 2146_ DPCRS 2151_ YVLPE 2156_ VICRS 2161_ CNFCR 2166_ DLDLC 2171_ KDSSF 2176_ SEDGA 2181_ VLPQW 2186_ LCSNC 2191_ QAPYD 2196_ SSAIE 2201_ MTLVE 2206_ VLQKK 2211_ LMAFT 2216_ LQDLV 2221_ CLKCR 2226_ GVKET 2231_ SMPVY 2236_ CSCAG 2241_ DFALT 2246_ IHTQV 2251_ FMEQI 2256_ GIFRN 2261_ IAQHY 2266_ GMSYL 2271_ LETLE 2276_ WLLQK 2281_NPQLG
1: Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)