Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
1_MVDTE 6_ SPLCP 11_ LSPLE 16_ AGDLE 21_ SPLSE 26_ EFLQE 31_ MGNIQ 36_ EISQS 41_ IGEDS 46_ SGSFG 51_ FTEYQ 56_ YLGSC 61_ PGSDG 66_ SVITD 71_ TLSPA 76_ SSPSS 81_ VTYPV 86_ VPGSV 91_ DESPS 96_ GALNI 101_ ECRIC 106_ GDKAS 111_ GYHYG 116_ VHACE 121_ GCKGF 126_ FRRTI 131_ RLKLV 136_ YDKCD 141_ RSCKI 146_ QKKNR 151_ NKCQY 156_ CRFHK 161_ CLSVG 166_ MSHNA 171_ IRFGR 176_ MPRSE 181_ KAKLK 186_ AEILT 191_ CEHDI 196_ EDSET 201_ ADLKS 206_ LAKRI 211_ YEAYL 216_ KNFNM 221_ NKVKA 226_ RVILS 231_ GKASN 236_ NPPFV 241_ IHDME 246_ TLCMA 251_ EKTLV 256_ AKLVA 261_ NGIQN 266_ KEAEV 271_ RIFHC 276_ CQCTS 281_ VETVT 286_ ELTEF 291_ AKAIP 296_ GFANL 301_ DLNDQ 306_ VTLLK 311_ YGVYE 316_ AIFAM 321_ LSSVM 326_ NKDGM 331_ LVAYG 336_ NGFIT 341_ REFLK 346_ SLRKP 351_ FCDIM 356_ EPKFD 361_ FAMKF 366_ NALEL 371_ DDSDI 376_ SLFVA 381_ AIICC 386_ GDRPG 391_ LLNVG 396_ HIEKM 401_ QEGIV 406_ HVLRL 411_ HLQSN 416_ HPDDI 421_ FLFPK 426_ LLQKM 431_ ADLRQ 436_ LVTEH 441_ AQLVQ 446_ IIKKT 451_ ESDAA 456_ LHPLL 461_QEIYR
1: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2