Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
1_MQPEE 6_ GTGWL 11_ LELLS 16_ EVQLQ 21_ QYFLR 26_ LRDDL 31_ NVTRL 36_ SHFEY 41_ VKNED 46_ LEKIG 51_ MGRPG 56_ QRRLW 61_ EAVKR 66_ RKALC 71_ KRKSW 76_ MSKVF 81_ SGKRL 86_ EAEFP 91_ PHHSQ 96_ STFRK 101_ TSPAP 106_ GGPAG 111_ EGPLQ 116_ SLTCL 121_ IGEKD 126_ LRLLE 131_ KLGDG 136_ SFGVV 141_ RRGEW 146_ DAPSG 151_ KTVSV 156_ AVKCL 161_ KPDVL 166_ SQPEA 171_ MDDFI 176_ REVNA 181_ MHSLD 186_ HRNLI 191_ RLYGV 196_ VLTPP 201_ MKMVT 206_ ELAPL 211_ GSLLD 216_ RLRKH 221_ QGHFL 226_ LGTLS 231_ RYAVQ 236_ VAEGM 241_ GYLES 246_ KRFIH 251_ RDLAA 256_ RNLLL 261_ ATRDL 266_ VKIGD 271_ FGLMR 276_ ALPQN 281_ DDHYV 286_ MQEHR 291_ KVPFA 296_ WCAPE 301_ SLKTR 306_ TFSHA 311_ SDTWM 316_ FGVTL 321_ WEMFT 326_ YGQEP 331_ WIGLN 336_ GSQIL 341_ HKIDK 346_ EGERL 351_ PRPED 356_ CPQDI 361_ YNVMV 366_ QCWAH 371_ KPEDR 376_ PTFVA 381_ LRDFL 386_ LEAQP 391_ TDMRA 396_ LQDFE 401_ EPDKL 406_ HIQMN 411_ DVITV 416_ IEGRA 421_ ENYWW 426_ RGQNT 431_ RTLCV 436_ GPFPR 441_ NVVTS 446_ VAGLS 451_ AQDIS 456_ QPLQN 461_ SFIHT 466_ GHGDS 471_ DPRHC 476_ WGFPD 481_ RIDEL 486_ YLGNP 491_ MDPPD 496_ LLSVE 501_ LSTSR 506_ PPQHL 511_ GGVKK 516_ PTYDP 521_ VSEDQ 526_ DPLSS 531_ DFKRL 536_ GLRKP 541_ GLPRG 546_ LWLAK 551_ PSARV 556_ PGTKA 561_ SRGSG 566_ AEVTL 571_ IDFGE 576_ EPVVP 581_ ALRPC 586_ APSLA 591_ QLAMD 596_ ACSLL 601_ DETPP 606_ QSPTR 611_ ALPRP 616_ LHPTP 621_ VVDWD 626_ ARPLP 631_ PPPAY 636_ DDVAQ 641_ DEDDF 646_ EICSI 651_ NSTLV 656_ GAGVP 661_ AGPSQ 666_ GQTNY 671_ AFVPE 676_ QARPP 681_ PPLED 686_ NLFLP 691_ PQGGG 696_ KPPSS 701_ AQTAE 706_ IFQAL 711_ QQECM 716_ RQLQA 721_ PAGSP 726_ APSPS 731_ PGGDD 736_ KPQVP 741_ PRVPI 746_ PPRPT 751_ RPHVQ 756_ LSPAP 761_ PGEEE 766_ TSQWP 771_ GPASP 776_ PRVPP 781_ REPLS 786_ PQGSR 791_ TPSPL 796_ VPPGS 801_ SPLPP 806_ RLSSS 811_ PGKTM 816_ PTTQS 821_ FASDP 826_ KYATP 831_ QVIQA 836_ PGPRA 841_ GPCIL 846_ PIVRD 851_ GKKVS 856_ STHYY 861_ LLPER 866_ PSYLE 871_ RYQRF 876_ LREAQ 881_ SPEEP 886_ TPLPV 891_ PLLLP 896_ PPSTP 901_ APAAP 906_ TATVR 911_ PMPQA 916_ ALDPK 921_ ANFST 926_ NNSNP 931_ GARPP 936_ PPRAT 941_ ARLPQ 946_ RGCPG 951_ DGPEA 956_ GRPAD 961_ KIQMA 966_ MVHGV 971_ TTEEC 976_ QAALQ 981_ CHGWS 986_ VQRAA 991_ QYLKV 996_ EQLFG 1001_ LGLRP 1006_ RGECH 1011_ KVLEM 1016_ FDWNL 1021_ EQAGC 1026_ HLLGS 1031_WGPAH
1: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370)