Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20)
1_MRAAA 6_ ISTPK 11_ LDKMP 16_ GMFFS 21_ ANPKE 26_ LKGTT 31_ HSLLD 36_ DKMQK 41_ RRPKT 46_ FGMDM 51_ KAYLR 56_ SMIPH 61_ LESGM 66_ KSSKS 71_ KDVLS 76_ AAEVM 81_ QWSQS 86_ LEKLL 91_ ANQTG 96_ QNVFG 101_ SFLKS 106_ EFSEE 111_ NIEFW 116_ LACED 121_ YKKTE 126_ SDLLP 131_ CKAEE 136_ IYKAF 141_ VHSDA 146_ AKQIN 151_ IDFRT 156_ RESTA 161_ KKIKA 166_ PTPTC 171_ FDEAQ 176_ KVIYT 181_ LMEKD 186_ SYPRF 191_ LKSDI 196_ YLNLL 201_NDLQA
1: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541)